题名

Effects of Hydrocortisone on Activation of Inflammation via Interleukin-33 in Ventilator-Induced Lung Injury

DOI

10.4077/CJP.2016.BAE409

作者

Shih-Hsing Yang；Jau-Chen Lin；Shih-Chi Peng；Fang Jung；Guoo-Shyng Wang Hsu；Guey-Mei Jow

关键词

IL-33 ； ventilator ； ventilator-induced lung injury

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

59卷5期（2016 / 10 / 31）

页次

284 - 292

内容语文

英文
英文摘要

Despite mechanical ventilation being a very important life-saving intervention, ventilator-induced lung injury (VILI) is related with inflammatory effects and causes high mortality. Our previous study demonstrated that the interleukin-33 (IL-33) cytokine pathway is a biomarker of VILI. The purpose of this study was to further explore the effects of hydrocortisone sodium succinate (HC) on pro-inflammatory IL-33 activation by VILI. The rats were intubated and received ventilation at 20 cmH_2O of inspiratory pressure (PC20) by a G5 ventilator for 4 h as a control group, and an intervention group received the same inspiratory pressure as well as treated with HC at 1 mg/kg at the third hour of ventilation (PC20+HC). The hemodynamic and respiratory data showed similar changes in the two groups that were exposed to VILI. The pathophysiological results showed that the HC treatment attenuated the VILI severity. Treatment of HC increased IL-33 expression in the bronchoalveolar lavage fluid (BALF). These results demonstrated that IL-33 is involved in VILI processing and HC treatment attenuated IL-33 involvement in inflammatory activation in VILI. In conclusion, IL-33 may play an important role in VILI.
主题分类 醫藥衛生 > 基礎醫學
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