Activation of IGF-I Survival Signaling and Its Compensative Inhibition of the Cardiac Apoptosis on Carotid Arteries Balloon-Injured Rat Hearts

10.4077/CJP.2017.BAF455

Cheng-Hong Hsieh；Peiying Pai；Jia-Ping Wu；Tsung-Jung Ho；Chieh-Hsi Wu；Marthandam Asokan Shibu；Cecilia Hsuan Day；Vijaya Padma Viswanadha；Ho-Lin Chuang；Chih-Yang Huang

cardiac apoptosis ； compensated hypertrophy ； decompensated hypertrophy ； IGF-I survival pathway ； percutaneous transluminal coronary angioplasty

The Chinese Journal of Physiology

60卷3期（2017 / 06 / 30）

166 - 173

英文

In this study, a rat carotid balloon injury-animal model was used to elucidate the temporal relation of hypertrophy in the progression of cardiac damage and the role of insulin-like growth factor (IGF)-I survival pathway on course of the cardiac damage. Rats were subjected to carotid balloon-injury and examined at different time points. We further studied the heart-weight/body-weight-ratio, histology and protein expression to understand the pathological events associated with percutaneous transluminal coronary angioplasty (PTCA) induced damages. Protein expression analysis showed increased levels of IGF-I signaling pathway and mitogen-activated protein kinase (MAPK) signaling pathway after 2 h and after 2 d of carotid balloon injury. On the other hand, apoptosis signaling pathways were enhanced after 14 d of carotid balloon injury. According to the results, rat carotid balloon injury significantly induced IGF-I survival signaling and compensated hypertrophy pathway during the initial period of injury however after 14 d the proteins involved in apoptotic cell death were elevated and the proteins of the survival pathway and compensatory hypertrophy were significantly reduced.

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