题名

Effects of B Vitamins Overload on Plasma Insulin Level and Hydrogen Peroxide Generation in Rats

DOI

10.4077/CJP.2017.BAF469

作者

Wuping Sun；Mingzhu Zhai；Qian Zhou；Chengrui Qian；Changyu Jiang

关键词

B vitamins ； insulin resistance ； nicotinamide ； nicotinic acid ； oxidative stress

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

60卷4期（2017 / 08 / 31）

页次

207 - 214

内容语文

英文
中文摘要

It has been reported that nicotinamide-overload induces oxidative stress associated with insulin resistance, the key feature of type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of B vitamins in T2DM. Glucose tolerance tests (GTT) were carried out in adult Sprague-Dawley rats treated with or without cumulative doses of B vitamins. More specifically, insulin tolerance tests (ITT) were also carried out in adult Sprague-Dawley rats treated with or without cumulative doses of Vitamin B3. We found that cumulative Vitamin B1 and Vitamin B3 administration significantly increased the plasma H_2O_2 levels associated with high insulin levels. Only Vitamin B3 reduced muscular and hepatic glycogen contents. Cumulative administration of nicotinic acid, another form of Vitamin B3, also significantly increased plasma insulin level and H_2O_2 generation. Moreover, cumulative administration of nicotinic acid or nicotinamide impaired glucose metabolism. This study suggested that excess Vitamin B1 and Vitamin B3 caused oxidative stress and insulin resistance.
主题分类 醫藥衛生 > 基礎醫學
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