题名

Infusion of Porcine-Derived Amniotic Fluid Stem Cells for Treatment of Experimental Colitis in Mice

DOI

10.4077/CJP.2017.BAG509

作者

Kun-Yi Lin；Shao-Yu Peng；Chih-Jen Chou；Herng-Sheng Lee；Leou-Chyr Lin；Ru-Yu Pan；Shinn-Chih Wu

关键词

colitis mouse model ； porcine amniotic fluid-derived stem cells

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

60卷6期（2017 / 12 / 31）

页次

345 - 352

内容语文

英文
中文摘要

Recently, stem cells have offered an alternative treatment for inflammatory bowel disease (IBD) or colitis to overcome the poor outcomes associated with current therapies. Amniotic fluid-derived stem cells (AFSCs) have the potential for the regeneration of impaired organs and the recovery of normal physiologic functions of damaged tissues without ethical concerns or risk of tumor formation. In this work, we aimed to examine the therapeutic effects of infusion of porcine AFSCs (pAFSCs) in dextran sulfate sodium (DSS)-induced colitis in mice. Treatment with pAFSCs was shown to inhibit the shortening of the colon after induction of colitis and dramatically ameliorated the body weight-loss induced by the DSS treatment. In addition, pAFSCs could also reduce the extent of the inflamed area represented by epithelial mesenchymal transformation in the colitis mice. The levels of the inflammatory cytokines interleukin 6 (IL-6) and interferon gamma (IFN-γ) were also reduced in colitis mice transplanted with pAFSCs. In conclusion, pAFSCs can ameliorate experimental colitis in mice, suggesting that they may be a potential treatment for IBD or colitis.
主题分类 醫藥衛生 > 基礎醫學
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