A Single Bout of Exercise Reduces Postprandial Lipemia but Has No Delayed Effect on Hemorheological Variables

10.4077/CJP.2018.BAG570

Chih-Hui Chiu；Tsung-Jen Yang；Hong Jen Liang；Cheng-Kang Chang；Ching-Lin Wu

blood viscosity ； endurance exercise ； erythrocyte aggregation degree ； hemorheology ； high-fat meal

The Chinese Journal of Physiology

61卷3期（2018 / 06 / 30）

181 - 187

英文

High plasma triglyceride (TG) concentration in fasting state could cause hemorheological abnormality, thus increasing the incidence of metabolic diseases. Exercise has been reported to effectively reduce postprandial TG response. This study aimed to investigate whether a single bout of pre-prandial exercise can affect lipemia and hemorheological variables after a high-fat meal. Nine healthy young male subjects completed two experimental trials. The subjects walked for 1 h at 50% maximal oxygen uptake (V̇O_(2max)) (the exercise, EX trial), or rested (the control, CON trial). In the next morning, the subjects consumed a high-fat meal, and the postprandial lipemia and hemorheological responses were monitored for 6 h. The results showed that postprandial plasma TG concentrations were significantly lower in the EX trial compared to the CON trial. The postprandial low-density lipoproteins (LDL) concentration declined in the first 2 h and then gradually returned to the baseline level in both trials. The postprandial blood viscosity also decreased in the CON trial. There was no significant difference in postprandial blood viscosity, red blood cell (RBC) deformation index and aggregation degree between the trials. There was no significant correlation between plasma TG concentration and blood viscosity. In conclusion, brisk walking effectively reduced postprandial TG concentration, but has no significant impact on postprandial blood viscosity, RBC deformation index and RBC aggregation index.

1. Ajmani, R.S.,Fleg, J.L.,Demehin, A.A.,Wright, J.G.,O'Connor, F.,Heim, J.M.,Tarien, E.,Rifkind, J.M.(2003).Oxidative stress and hemorheological changes induced by acute treadmill exercise.Clin. Hemorheol. Microcirc.,28,29-40.
2. Babu, N.(2009).Influence of hypercholesterolemia on deformability and shape parameters of erythrocytes in hyperglycemic subjects.Clin. Hemorheol. Microcirc.,41,169-177.
3. Chiu, C.H.,Burns, S.F.,Yang, T.J.,Chang, Y.H.,Chen, Y.L.,Chang, C.K.,Wu, C.L.(2014).Energy replacement using glucose does not increase postprandial lipemia after moderate intensity exercise.Lipids Health Dis.,13,1.
4. Cicha, I.,Suzuki, Y.,Tateishi, N.,Maeda, N.(2001).Enhancement of red blood cell aggregation by plasma triglycerides.Clin. Hemorheol. Microcirc.,24,247-256.
5. Cicha, I.,Suzuki, Y.,Tateishi, N.,Maeda, N.(2004).Effects of dietary triglycerides on rheological properties of human red blood cells.Clin. Hemorheol. Microcirc.,30,301-306.
6. Contreras, T.,Vayá, A.,Palanca, S.,Sola, E.,Corella, D.,Aznar, J.(2004).Influence of plasmatic lipids on the hemorheological profile in healthy adults.Clin. Hemorheol. Microcirc.,30,423-426.
7. Ernst, E.(1987).Influence of regular physical activity on blood rheology.Eur. Heart J.,8,59.
8. Forsyth, A.M.,Braunmüller, S.,Wan, J.,Franke, T.,Stone, H.A.(2012).The effects of membrane cholesterol and simvastatin on red blood cell deformability and ATP release.Microvasc. Res.,83,347-351.
9. Frayn, K.(1983).Calculation of substrate oxidation rates in vivo from gaseous exchange.J. Appl. Physiol.,55,628-634.
10. Friedewald, W.T.,Levy, R.I.,Fredrickson, D.S.(1972).Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.Clin. Chem.,18,499-502.
11. Gill, J.M.,Hardman, A.E.(2003).Exercise and postprandial lipid metabolism: an update on potential mechanisms and interactions with high-carbohydrate diets.J. Nutr. Biochem.,14,122-132.
12. Gill, J.M.,Herd, S.L.,Vora, V.,Hardman, A.E.(2003).Effects of a brisk walk on lipoprotein lipase activity and plasma triglyceride concentrations in the fasted and postprandial states.Eur. J. Appl. Physiol.,89,184-190.
13. Gliemann, L.,Schmidt, J.F.,Olesen, J.,Biensø, R.S.,Peronard, S.L.,Grandjean, S.U.,Mortensen, S.P.,Nyberg, M.,Bangsbo, J.,Pilegaard, H.(2013).Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men.J. Appl. Physiol.,591,5047-5059.
14. Irace, C.,Scavelli, F.,Carallo, C.,Serra, R.,Gnasso, A.(2009).Plasma and blood viscosity in metabolic syndrome.Nutr. Metab. Cardiovasc. Dis.,19,476-480.
15. Jeong, S.K.,Cho, Y.I.,Duey, M.,Rosenson, R.S.(2010).Cardiovascular risks of anemia correction with erythrocyte stimulating agents: should blood viscosity be monitored for risk assessment?.Cardiovasc. Drugs Ther.,24,151-160.
16. Koenig, W.,Ernst, E.(1992).The possible role of hemorheology in atherothrombogenesis.Atherosclerosis,94,93-107.
17. Liu, D.Z.,Chien, S.C.,Tseng, L.P.,Yang, C.B.(2003).The influence of hyperbaric oxygen on hemorheological parameters in diabetic rats.Biorheology,40,605-612.
18. Maeda, N.,Cicha, I.,Tateishi, N.,Suzuki, Y.(2006).Triglyceride in plasma: prospective effects on microcirculatory functions.Clin. Hemorheol. Microcirc.,34,341-346.
19. Martínez, M.,Vayá, A.,Martí, R.,Gil, L.,Lluch, I.,Carmena, R.,Aznar, J.(1996).Erythrocyte membrane cholesterol/phospholipid changes and hemorheological modifications in familial hypercholesterolemia treated with lovastatin.Thromb. Res.,83,375-388.
20. Mel'nikov, A.A.,Vikulov, A.D.(2004).Blood rheology, sex hormones, and cortisol in athletes.Human Physiol.,30,596-604.
21. Miyashita, M.,Tokuyama, K.(2008).Moderate exercise reduces serum triacylglycerol concentrations but does not affect pre-heparin lipoprotein lipase concentrations after a moderate-fat meal in young men.Brit. J. Nutr.,99,1076-1082.
22. Pattyn, N.,Cornelissen, V.A.,Eshghi, S.R.T.,Vanhees, L.(2013).The effect of exercise on the cardiovascular risk factors constituting the metabolic syndrome.Sports Med.,43,121-133.
23. Seip, R.L.,Mair, K.,Cole, T.G.,Semenkovich, C.F.(1997).Induction of human skeletal muscle lipoprotein lipase gene expression by short-term exercise is transient.Am. J. Physiol. Endocrinol. Metab.,272,255-261.
24. Sloop, G.D.,Bialczak, J.K.,Weidman, J.J.,St Cyr, J.(2016).Uric acid increases erythrocyte aggregation: Implications for cardiovascular disease.Clin. Hemorheol. Microcirc.,63,349-359.
25. Tai, C.J.,Chen, C.H.,Chen, H.H.,Liang, H.J.(2010).Differential effect of high dietary fat intakes on haemorheological parameters in rats.Brit. J. Nutr.,103,977.
26. Vandewalle, H.,Lacombe, C.,Lelievre, J.,Poirot, C.(1988).Blood viscosity after a 1-h submaximal exercise with and without drinking.Int. J. Sports Med.,9,104-107.
27. Vayá, A.,Hernández-Mijares, A.,Bonet, E.,Sendra, R.,Solá, E.,Pérez, R.,Corella, D.,Laiz, B.(2011).Association between hemorheological alterations and metabolic syndrome.Clin. Hemorheol. Microcirc.,49,493-503.
28. Waltz, X.,Hedreville, M.,Sinnapah, S.,Lamarre, Y.,Soter, V.,Lemonne, N.,Etienne-Julan, M.,Beltan, E.,Chalabi, T.,Chout, R.(2012).Delayed beneficial effect of acute exercise on red blood cell aggregate strength in patients with sickle cell anemia.Clin. Hemorheol. Microcirc.,52,15-26.
29. Wang, X.W.,Hu, L.,Zeng, Z.,Yao, W.J.,Han, J.Y.,Zhang, Y.Y.,Xu, X.F.,Liu, Y.Y.,Ka, W.B.,Sun, D.G.(2008).Effects of myakuryu on hemorheological characteristics and mesenteric microcirculation of rats fed with a high-fat diet.Biorheology,45,587-598.
30. Yalcin, O.,Erman, A.,Muratli, S.,Bor-Kucukatay, M.,Baskurt, O.K.(2003).Time course of hemorheological alterations after heavy anaerobic exercise in untrained human subjects.J. Appl. Physiol.,94,997-1002.
31. Zhao, T.,Guo, J.,Li, H.,Huang, W.,Xian, X.,Ross, C.J.D.,Hayden, M.R.,Wen, Z.,Liu, G.(2006).Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia.Biochem. Biophys. Res. Commun.,341,1066-1071.