题名

Autophagy: A Potential Target for Rescuing Sepsis-induced Hepatic Failure

DOI

10.4103/CJP.CJP_25_19

作者

Chin Hsu

关键词

Autophagy ； hepatic failure ； sepsis

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

62卷2期（2019 / 04 / 30）

页次

53 - 62

内容语文

英文
中文摘要

Sepsis is the leading cause of death in intensive care units worldwide; however, it remains a scientific and clinical challenge in modern medicine. An excessive inflammatory response associated with high level of reactive oxygen species results in mitochondrial dysfunction and activation of the unfolded protein response leading to subsequent energetic organ failure in septic patients. In addition to blocking the inflammatory cascade directly, new strategies focusing on host endogenous adaption to severe infection may hold better promise for improving outcomes in septic patients. Autophagy is a fundamental cellular response to stress and pathogen invasion. The study of autophagic responses to sepsis is a critical component of understanding the mechanisms by which tissues respond to infection. This review aims at elucidating the role of autophagy in sepsis‑induced hepatic failure and further explores the possible factor that suppresses autophagy and potential targets of augmenting autophagy, in an effort to provide a new perspective for the clinical treatment of sepsis‑induced hepatic failure.
主题分类 醫藥衛生 > 基礎醫學
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