题名

Mechanistic Insight of Cyclin-Dependent Kinase 5 in Modulating Lung Cancer Growth

DOI

10.4103/CJP.CJP_67_19

作者

G. M. Shazzad Hossain Prince；Tsung-Ying Yang；Ho Lin；Mei-Chih Chen

关键词

CDK5 ； cytoskeletal remodeling ； DNA damage ； lung cancer ； PD-L1 ； tumor suppressor

期刊名称

The Chinese Journal of Physiology

卷期/出版年月

62卷6期（2019 / 12 / 31）

页次

231 - 240

内容语文

英文
中文摘要

Lung harbors the growth of primary and secondary tumors. Even though numerous factors regulate the complex signal transduction and cytoskeletal remodeling toward the progression of lung cancer, cyclin-dependent kinase 5 (Cdk5), a previously known kinase in the central nervous system, has raised much attention in the recent years. Patients with aberrant Cdk5 expression also lead to poor survival. Cdk5 has already been employed in various cellular processes which shape the fate of cancer. In lung cancer, Cdk5 mainly regulates tumor suppressor genes, carcinogenesis, cytoskeletal remodeling, and immune checkpoints. Inhibiting Cdk5 by using drugs, siRNA or CRISP-Cas9 system has rendered crucial therapeutic advantage in the combat against lung cancer. Thus, the relation of Cdk5 to lung cancer needs to be addressed in detail. In this review, we will discuss various cellular events modulated by Cdk5 and we will go further into their underlying mechanism in lung cancer.
主题分类 醫藥衛生 > 基礎醫學
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