Cell Response in Bronchoalveolar Lavage Fluid after Sulfur Dioxide Exposure

Thomas Sandström；Nils Stjernberg；Maj-Cari Andersson；Birgitta Kolmodin-Hedman；Karin Lindstrom；Leif Rosenhall

lymphocytes ； lysozyme ； macrophages ； mast cells

Scandinavian Journal of Work, Environment & Health

15卷2期（1989 / 03 / 01）

142 - 146

英文

Environmental chamber exposure and bronchoalveolar lavage (BAL) were used to study the dose-response relation ship between short-term exposure to sulfur dioxide (SO2) and inflammatory reactions in the human lung as reflected in BAL fluid. Healthy subjects were exposed to 10, 13, 20, or 30 mg/m^3 for 20 min. BAL was performed several weeks preexposure and 24 h postexposure. Mast cells, lymphocytes, lysozyme positive macrophages, and the total number of macrophages were significantly increased after SO2 exposure. A dose-dependent increase in the cell response in BAL fluid was observed after exposure to 10-20 mg/m^3, but no further increase was detected after 30 mg/m^3. Inflammatory cell response was found in BAL fluid at SO2 levels that occur in industrial indoor environments worldwide, and cell response to SO2 was also seen below the short-term exposure limit of Sweden and many other countries (13 mg/m^3).