Measurement of Organic Halogen Compounds in Urine as an Indicator of Exposure

Mirja S Salkinoja-Salonen；Jouni K Jokela

adsorbable organic halogen ； excreted ； pollutant

Scandinavian Journal of Work, Environment & Health

17卷1期（1991 / 01 / 01）

75 - 78

英文

The report describes the measurement of urinary organic halogen compounds. The method is an application of the adsorbable organic halogen assay which is widely used for the analysis of industrial waste water and drinking water. It was found that this assay can be applied to human urine if the urine is pretreated to hydrolyze the mucins so as to cleave the neuraminic acid residues responsible for the high viscosity of these slimy proteins. The method was found to be sensitive down to 1 μg of organic halogen/100ml of urine. Fifty to 260 μg of organic halogen was measured in the night urine of healthy, occupationally unexposed volunteers. Since many toxic chemicals to which man may be exposed environmentally or occupationally are, in fact, halogen compounds, this assay may be used to monitor for human exposure.