Detection of Chromosomal Fragile Sites Using Simultaneous Confidence Intervals for Fragility Probabilities

10.29973/JCSA.200406.0005

Chia-Ding Hou；John Jen Tai

Adjusted comparison procedure ； familywise error rate ； fixed comparison procedure

中國統計學報

42卷2期（2004 / 06 / 01）

169 - 181

英文

Chromosomal fragile sites have recently excited considerable interest because of their remarkable association with the origins of chromosomal rearrangements of malig-nancy. There have been many methods developed for detection of fragile sites, either by a simple-stage binomial model or a multi-stage changeable multinomial model. Both models require a pre-existing hypothesis setting for the establishment of the compari-son base between the null hypothesis (random breakage) and the alternative hypothesis (nonrandom breakage). When there are a large number of sites for simultaneous test, such a hypothesis testing approach is not easy to analyze the breakage data incorporat-ing the band order, and is difficult to control and estimate the familywise error rate. In this article, simultaneous con_dence intervals (SCIs) for selected linear combinations of chromosomal breakage probabilities are used to detect fragile sites and to investi-gate possible relationships among chromosomal fragility probabilities. This approach controls the type I familywise error rate and is a fixed comparison rocedure procedure.

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