Thyrotropin Releasing Hormone Affects the Lateral Hypothalamus to Induce Hyperglycemia in the Rat

甲狀腺素刺激素釋放素經由下視丘外側核作用以誘發血糖升高

沈德昌(D. C. Shen)；宣立人(L. R. Shian)；林茂村(M. T. Lin)；陳雲峯(Y. F. Chern)

Journal of Medical Sciences

5卷3期（1984 / 06 / 01）

1865 - 1872

英文

本研究旨在於觀測在下視丘內注入微量的甲狀腺素刺激素釋放素對於麻醉中大白鼠血糖調節之影響。將此劑注入於下視丘之外側核可引發血糖上升。將此劑注入於下視丘之腹內側核及附近地區則不影響血糖。將本劑注入下視丘外側核所引起的血糖升高反應會因為事先施行兩側迷走神經切除，阿托平處理，兩側腎上腺切除，或脊體截斷（在第七頸脊髓處）而大大地減弱或完全消失。同時，可見兩側腎上腺切除鼠表現出低於對照鼠之血糖濃度。反之，迷走神經切除鼠或阿托平處理鼠則表現高於對照鼠之血糖濃度。由本結果推論：本劑可能經由作用於下視丘外側核的控制機會轉以提升腎上腺髓質－交感神經傳出活動性以及降低副交感神經傳出活動性，因而引起血糖上昇。

The effects of microinjection of thyrotropin releasing hormone (TRH) into the hypothalamus on glucoregulation were assessed in rats under pentobarbital sodium anesthesia. Administration of TRH (1-40 μg in 1.0 μl volume) into the lateral hypothalamus, but not the ventromedial hypothalamus, caused an increase in blood glucose. The hyperglycemia in response to intrahypothalamic administration of TRH were greatly reduced in rats pretreated with spinal cord transaction (at C7), adrenectomy, vagotomy or atropinization. In addition, it was found that, as compared to that of the control animals, adrenectomized rats displayed a lower level of blood glucose, whereas vagotomized rats or rats with atropinization had a higher level of blood glucose. The data indicate that TRH may act through the control mechanism within the lateral hypothalamus to induce hyperglycemia by promoting an increase in the adrenal-sympathetic efferent activity and a decrease in the vagal tone.