INER Sterile 113m In-Generator-Its Preparation and Medical Applications

Tong-Bao Chen；Shyong Lin；Daw-Quey Tsay；Shin-Hwa Yeh

Journal of Medical Sciences

5卷3期（1984 / 06 / 01）

1881 - 1887

英文

The enriched tin-112 metal up to 83% was irradiated at TRR (Taiwan Research Reactor) with neutron flux of about 5×10^(13) n/cm^2/sec for at least 180 days. The generator was made by adsorbing the 0.2N HCl solution of Sn-113 species into the hydrated zirconium oxide column. Milking of In-113m was achieved by 0.05N HCl. The quality control of the In-113m eluate demonstrated that the generator has met the USP standard. The biodistribution in white rat revealed that the In-113m tracer was concentrated in the blood, kidney and liver. The human blood clearance rate indicated that a high level concentration of radiotracer was maintained 8 hours in the blood after injection and was decreased rapidly to the ground level at the 12th hour. The urine clearance rate was 23% during the first 24 hours after injection. The liver perfusion and placenta localization study demonstrated that the quality of the In-113m tracer from the generator was satisfactory for medical applications.