Neuromuscular Effects of Fentanyl in the Rat Phrenic Nerve-Diaphragm Preparation

Fentanyl在大白鼠膈神經－橫膈製備模式之神經肌肉效應

葉富欽(Fuh-Cheng Yeh)；謝介平(Ja-Ping Shieh)；顏茂雄(Mao-Hsiung Yen)

橫膈 ； 骨酪肌收縮力 ； Fentanyl ； Diaphragm ； Skeletal muscle contractility

Journal of Medical Sciences

10卷2期（1989 / 04 / 01）

67 - 72

英文

Fentanyl is a short-acting opioid analgesic agent widely used in clinical anesthesia. It may induce muscle righdity which has been suggested to be central origin. The direct effect of fentanyl on skeletal muscles is still unknown. We studied the effects of fentanyl on skeletal muscle tonus and contractility in 10 rat phrenic nerve-hemidiaphragm preparations. The d diaphragmatic witch tension upon electrical stimulation of the phrenic nerve was evaluated before and after fentanyl administrations. Cumulative concentraions of fentanyl 5, 10, 50, 100, 150, 200, 300 and 400 ng/ml were used in this study. There were no significant changes of twitch tension in the concentration ranges of 5 to 100 ng/ml. A slight dose-dependent depression in twitch tension was observed at high concentrations of fentanyl. Fentanyl at concentrations of 150, 200, 300 and 400 ng/ml exerted a depression of the twitch tension by 2.2 ± 0.6%, 3.3 ± 0.9%, 6.3 ± 1.3% and 8.2 ± 0.9%, respectively from the baseline value. Results indicate that fentanyl does not induce skeletal muscle righdity directly. On the contrary, a direct depression on muscle twitch tension in diaphragm preparations is fond at high concentrations of fentanyl.

Fentanyl is a short-acting opioid analgesic agent widely used in clinical anesthesia. It may induce muscle righdity which has been suggested to be central origin. The direct effect of fentanyl on skeletal muscles is still unknown. We studied the effects of fentanyl on skeletal muscle tonus and contractility in 10 rat phrenic nerve-hemidiaphragm preparations. The d diaphragmatic witch tension upon electrical stimulation of the phrenic nerve was evaluated before and after fentanyl administrations. Cumulative concentraions of fentanyl 5, 10, 50, 100, 150, 200, 300 and 400 ng/ml were used in this study. There were no significant changes of twitch tension in the concentration ranges of 5 to 100 ng/ml. A slight dose-dependent depression in twitch tension was observed at high concentrations of fentanyl. Fentanyl at concentrations of 150, 200, 300 and 400 ng/ml exerted a depression of the twitch tension by 2.2 ± 0.6%, 3.3 ± 0.9%, 6.3 ± 1.3% and 8.2 ± 0.9%, respectively from the baseline value. Results indicate that fentanyl does not induce skeletal muscle righdity directly. On the contrary, a direct depression on muscle twitch tension in diaphragm preparations is fond at high concentrations of fentanyl.