Squamous Cell Carcinoma of the Lung Following Adult-onset Recurrent Respiratory Papillomatosis

10.6136/JMS.2008.28(1).053

Kuo-An Wu；Wann-Cherng Perng；Chih-Kung Lin；Wei-Teing Chen；Horng-Chin Yan

recurrent respiratory papillomas ； adult-onset recurrent respiratory papillomatosis ； human papilloma virus ； squamous cell carcinoma

Journal of Medical Sciences

28卷1期（2008 / 02 / 01）

53 - 56

英文

Malignant transformations of recurrent respiratory papillomatosis (RRP) are rare, and are usually associated with prior radiation therapy or a history of smoking. In this report, we describe an uncommon case of a 54-year-old woman with no history of either irradiation or active smoking, who developed squamous cell carcinoma of the lung from adult-onset recurrent respiratory papillomatosis (AO-RRP) with lung involvement in the 10-year follow-up period. Serial chest radiographs and computed tomography scans showed widely scattered parenchymal lesions, both solid and cavitary, central and peripheral. The lung lesions grew slowly and some became confluent. To the best of our knowledge, squamous cell carcinoma of the lung is a rare complication of RRP without a history of irradiation or smoking.