| 题名 |
The Effect of Intensified Low Density Lipoprotein Cholesterol Reduction on Recurrent Myocardial Infarction and Cardiovascular Mortality |
| 作者 |
Wei-Chun Huang；Tzu-Wen Lin；Kuan-Rau Chiou；Chin-Chang Cheng；Feng-Yu Kuo；Cheng-Hung Chiang；Jin-Shiou Yang；Ko-Long Lin；Shin-Hung Hsiao；Tong-Chen Yeh；Guang-Yuan Mar；Hsiong-Chiong Hsiao；Shoa-Lin Lin；Chuen-Wang Chiou；Chun-Peng Liu |
| 关键词 |
Acute myocardial infarction ； Cardiovascular death ； Low-density lipoprotein cholesterol ； Mortality ； Statin |
| 期刊名称 |
Acta Cardiologica Sinica |
| 卷期/出版年月 |
29卷5期（2013 / 09 / 01） |
| 页次 |
404 - 412 |
| 内容语文 |
英文 |
| 英文摘要 |
Background: Lipid-lowering therapy plays an important role in preventing the recurrence of cardiovascular events in patients after acute myocardial infarction (AMI). This study aimed to assess the effect of intensified low density lipoprotein cholesterol (LDL-C) reduction on recurrent myocardial infarction and cardiovascular mortality in patients after AMI.Method: The 562 enrolled AMI patients (84.2% male) were divided into two groups according to 3-month LDL-C decrease percentage equal to or more than 40% (n = 165) and less than 40% (n = 397). To evaluate the long-term efficacy of LDL-C reduction, the 5-year outcomes were collected, including time to the first occurrence of myocardial infarction and time to cardiovascular death.Results: The baseline characteristics and complication rates were not different between the two study groups. The patients with 3-month LDL-C decrease ≧ 40% had higher baseline LDL-C and lower 3-month, 1-year, 2-year, 3-year, 4-year and 5-year LDL-C than the patients with 3-month LDL-C decrease ＜ 40%. In Kaplan-Meier analyses, those patients with 3-month LDL-C decrease ≧ 40% had a higher rate of freedom from myocardial infarction (p = 0.006) and survival rate (p = 0.02) at 5-year follow-up. The 3-month LDL-C ＜ 40% parameter was significantly related to cardiovascular death (HR: 9.62, 95% Cl1.18-78.62, P ＜ 0.04).Conclusions: After acute myocardial infarction, 3-month LDL-C decrease ＜ 40% was identified to be a significant risk factor for predicting 5-year cardiovascular death. The patients with 3-month LDL-C decrease ≧ 40% had a higher rate of freedom from myocardial infarction and lower cardiovascular mortality, even though these patients had higher baseline LDL-C value. |
| 主题分类 |
醫藥衛生 >
內科 醫藥衛生 > 外科 |
| 被引用次数 |
