Uremic Toxins-Novel Arrhythmogenic Factor in Chronic Kidney Disease-Related Atrial Fibrillation

10.6515/ACS20151116A

Shih-Yu Huang；Yi-Ann Chen；Shih-Ann Chen；Yi-Jen Chen；Yung-Kuo Lin

Atrial fibrillation ； Inflammation ； Oxidative stress ； Uremic toxins

Acta Cardiologica Sinica

32卷3期（2016 / 05 / 01）

259 - 264

英文

Atrial fibrillation (AF) is the most common cardiac arrhythmia. Chronic kidney disease (CKD) is associated with a high prevalence of AF, and uremic toxins are an important risk factor for cardiovascular diseases associated with CKD. Uremic toxins can produce pro-fibrotic, pro-hypertrophic, and pro-inflammatory effects on cardiac tissues and enhance oxidative stress or neurohormonal phenomena of cardiovascular injury, which are recognized as arrhythmogenic factors of AF. This article reviews the clinical, molecular, and electrophysiological data of uremic toxins in CKD considered to induce AF through multiple mechanisms on structural and electrical remodeling of the cardiovascular system.