Cutaneous Hypersensitivity to Icodextrin: Cases Report and Brief Review

10.6221/AN.202006_34(2).0006

Chun Chang；Chiao-Yin Sun

cutaneous hypersensitivity ； icodextrin ； peritoneal dialysis ； end stage renal disease ； allergy

Acta Nephrologica

34卷2期（2020 / 06 / 01）

98 - 106

英文

Icodextrin is an osmotic agent used as an alternative to glucose for peritoneal dialysis (PD). Cutaneous adverse effects due to icodextrin usage have been reported in the literature but are uncommon. In this study, we report two cases of maculopapular eruption associated with icodextrin usage and review reported cases of icodextrin-related cutaneous hypersensitivity. The results indicated that icodextrin-related cutaneous hypersensitivity occurred approximately 2 weeks after exposure to icodextrin. The influenced age ranges from 41 to 60 years. Most cases recovered within 2 weeks after icodextrin withdrawal. Although the safety and efficacy of icodextrin PD solution are well documented, clinicians should be mindful of the possibility of adverse cutaneous reactions to the icodextrin dialysate.