The Correlation Between 24 - Hour - Urine Protein and Spot Urine Protein/Creatinine Ration and the Inconstancy of Daily Urine Protein and Creatinine Excretion

24小時尿蛋白與單次尿蛋白／尿肌酸酐比值間關係及每日尿蛋白肌酸酐排泄量之非衡定性。

10.6440/TZUCMJ.199206.0100

萬象(Shianq Wann)；郭泰松(Tai-Son Kuo)

蛋白尿 ； 肌酸酐廓清率 ； 24小時尿蛋白 ； Proteinuria ； creatinine clearance ； 24 hours urine protein

慈濟醫學雜誌

4卷2期（1992 / 06 / 01）

100 - 105

英文

Twenty-four-hour urine protein is measured for diagnosis of early renal disease and it is an important diagnostic test of nephritic syndrome. Creatinine clearance (Ccr) is commonly used as index of renal function and used for following the progress of renal function. The daily urine collection is inconvenient and difficult. We tried to evaluate the possibility to use the single voided urine protein/creatinine (prot/creat) ratio substituting 24 hours urine protein examination. We collected 24 hours urine and a random single urine on the same day from 100 ambulatory outpatients. In other hand, we also collected 24 hours urine for 4 days and single urine at 7:00am, 11:00am, 5:00pm and 9:00pm respectively in the first day from 26 inpatients with urine catheter. Their renal functions are stable. All the urine samples were sent for protein and creatinine measurements. The results showed good correlations between prot/creat ration and 24 hours urine protein (r=0.72 in outpatients; r=0.75-0.85 in inpatients, all p＜0.01). The incidences of high variance (CV ＞ 15%) in sequential days’s24 hours urine creatinine and protein excretion, and Ccr are 30.8%, 65.4% and 61.5% respectively. In conclusion: random single urine prot/creat ratio may be as an alternative of 24 hours urine protein detection. The daily urine protein and creatinine excretion, and Ccr are not so steady in a lot of patients.

Twenty-four-hour urine protein is measured for diagnosis of early renal disease and it is an important diagnostic test of nephritic syndrome. Creatinine clearance (Ccr) is commonly used as index of renal function and used for following the progress of renal function. The daily urine collection is inconvenient and difficult. We tried to evaluate the possibility to use the single voided urine protein/creatinine (prot/creat) ratio substituting 24 hours urine protein examination. We collected 24 hours urine and a random single urine on the same day from 100 ambulatory outpatients. In other hand, we also collected 24 hours urine for 4 days and single urine at 7:00am, 11:00am, 5:00pm and 9:00pm respectively in the first day from 26 inpatients with urine catheter. Their renal functions are stable. All the urine samples were sent for protein and creatinine measurements. The results showed good correlations between prot/creat ration and 24 hours urine protein (r=0.72 in outpatients; r=0.75-0.85 in inpatients, all p＜0.01). The incidences of high variance (CV ＞ 15%) in sequential days’s24 hours urine creatinine and protein excretion, and Ccr are 30.8%, 65.4% and 61.5% respectively. In conclusion: random single urine prot/creat ratio may be as an alternative of 24 hours urine protein detection. The daily urine protein and creatinine excretion, and Ccr are not so steady in a lot of patients.