Circulating CD4 Positive B Cells in Taiwanese Patients with Rheumatoid Arthritis

類風濕性關節炎病人周邊血液之CD5陽性B淋巴球之研究

10.6440/TZUCMJ.199409.0145

劉明輝(Ming-Fei Liu)；黎煥耀(Huan-Yao Lei)

CD5 antigen ； B lymphocyte ； rheumatoid arthritis ； CD5抗原 ； B淋巴球 ； 類風濕性關節炎

慈濟醫學雜誌

6卷3期（1994 / 09 / 01）

145 - 151

英文

表現CD5標誌之B淋巴球，其所產生之免疫球蛋白，常可與自已成份結合，因此被認為在自體免疫疾病中可能扮演重要角色。以住，許多在洋人所做的研究都顯示此類B淋巴球在類風濕性關節炎病人呈現明顯的增加。但由最近一些報告，發現此類淋巴球之多寡似乎由遺傳基基所控制。我們乃以29位中國病人為究對象，測其血中此類CD5陽性B淋巴球所佔之比例。結果，我們發現類風濕性關節炎病人之CD5陽性B淋巴球並沒有較正常人多。同時，病人之此類B細胞之多寡也與疾病嚴重程度，或類風濕因子濃度高低沒有密切關聯。在六位病人一年之追蹤下，也顯示CD5陽性B細胞在個人都維持頗為隱定之比例。因此，我們結論認為在國人之類風濕性關節炎疾病，CD5陽性B淋巴球並不扮演重要角色。此類B細胞之多寡受個人遺傳基因所影響。(慈濟醫學1994;6: 145-151)

Most studies conducted in Caucasians showed increased circulating CD5 positive B lymphocytes in rheumatoid arthritis (RA) patients. Since CD5+B cells expression appeared to be under genetic control, we investigated its distribution in twenty-nine Taiwanese patients with RA. Cir-culating CD+5 B cell levels were analyzed by flow cytometry. There was no elevation of CD5+B cells in RA patients compared with healthy subjects. The population of CD5+B cells correlated neither with titers of serum rheumatoid factors (RFs) nor with disease activities in RA patients. The proportion of CD5+B cells in the peripheral blood remained relatively constant after one year follow-up studies in six patients. The similar pattern of epitope density of CD5 antigens was also observed in the same individual. We thus concluded that circulating CD5+B lymphocytes played little role in the pathogenesis of RA. Levels of CD5+B cells reflected more individual genetic background rather than susceptible marker for RA in Taiwanese. (Tzu-Chi Med J 1994; 6: 145-151)