Cytogenetic Analysis of Human Uterine Leiomyomas

10.30047/JGMB.199412.0007

L. C. Kuan；T. C. Kuo；Z. T. Chang；S. C. Lin；P. L Tu；C. W. Tsai；T. M. Kuo；K. T. Kuo

Journal of Genetics and Molecular Biology

5卷4期（1994 / 12 / 01）

76 - 76

英文

Cytogenetic analysis of 33 uterine leiomyomas showed abnormal karyotypes in 11 cases. In 9 of 11 aberrant tumors, normal cells were also observed. Structural changes were most frequent, resulting in modal chromosome numbers in the diploid range. Our data confirmed preferential breakpoint clusters at 1 p34.2, 3 q13.3, 6 q21, 6 q24, 7 q31.2, 11 p12, 12 q15, 14 q24. We also found monosomy 22, ring chromosome 1 and 4 in uterine leiomyomas. Statistical analysis of possible relationships between tumor karyotypes (abnormal versus normal) and clinico – patho – logical data, as well as age of the patients, menopausal status and tumor size showed specific significance between myoma nodule size and abnormal karyotypes.(P value ＜ 0.05). We concluded that while many uterine myomas have normal karyotypes, clonal chromosome abnormalities are presented in 36.7% of these tumors. The study of chromosome rearrangements in benign tumors might be helpful in defining chromosome regions associated with abnormal proliferation of cells.