早期子宮頸癌病患治療後長期的生活品質之研究

Long-term Quality of Life for Patients with Early Stage Uterine Cervical Carcinoma after Treatment

許維中(Wei-Chung Hsu)；鍾娜娜(Na-Na Chung)；陳宇嘉(Yu-Chia Chen)；詹淑卿(Sue-Ching Chan)；丁禮莉(Lai-Lei Ting)；蔡崇煌(Chung-Huang Tsai)；王雪鳳(Hsueh-Feng Wang)；王博民(Po-Ming Wang)；林高德(Gau-De Lin)

生活品質 ； 放射治療 ； 子宮頸癌 ； EORTC ； Quality of life ； Radiotherapy ； Uterine cervical cancer

中華放射線醫學雜誌

29卷1期（2004 / 02 / 01）

21 - 28

繁體中文

To compare the difference between treatment modalities for long-term quality of life (QoL) in patients with early stage uterine cervical carcinoma. From March 2002 to April 2003, two hundred and seventeen patients of two institutions were invited to participate. Inclusive patients were followed for at least 2 years after the completion of the treatment. They were divided into 2 groups by different treatment modalities: surgery with postoperative radiation therapy (OP+RT) and radiation therapy alone (RT alone). QoL were assessed by means of the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ C-30) and side effects for uterine cervical cancer after treatment. Relative high side effects in early stage uterine cervical cancer patient treated by OP+RT were: constipation (46.8%, p＜0.001), edema of lower extremities (24.3%, p=0.004), urine incontinence (40.5%, p=0.041) and hot flush (13.5%, p=0.050). Relative high side effects in early stage uterine cervical cancer patient treated by RT alone were: diarrhea (45.3%, p=0.008) and increased vaginal discharge (14.2%, p=0.029). The EORTC QLQ C-30 QoL items were significant better in OP+RT groups as comparison with RT alone group, including global health statues (p=0.043), cognitive function (p=0.033), social function (p=0.037), nausea/vomiting (p=0.027), pain(p=0.031), poor appetite (p=0.009) and financial problem (p=0.009). Constipation was worse significantly in OP+RT group than in RT alone group (p=0.002). Our study provided comparison and analysis of long-term QoL and side effects in early stage uterine cervical cancer patients treated by different modalities. These data were helpful for clinical physician not only for selecting treatment modalities when concerning with QoL of the patients, but also for rehabilitation and supportive care of the patients after treatment.

To compare the difference between treatment modalities for long-term quality of life (QoL) in patients with early stage uterine cervical carcinoma. From March 2002 to April 2003, two hundred and seventeen patients of two institutions were invited to participate. Inclusive patients were followed for at least 2 years after the completion of the treatment. They were divided into 2 groups by different treatment modalities: surgery with postoperative radiation therapy (OP+RT) and radiation therapy alone (RT alone). QoL were assessed by means of the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ C-30) and side effects for uterine cervical cancer after treatment. Relative high side effects in early stage uterine cervical cancer patient treated by OP+RT were: constipation (46.8%, p＜0.001), edema of lower extremities (24.3%, p=0.004), urine incontinence (40.5%, p=0.041) and hot flush (13.5%, p=0.050). Relative high side effects in early stage uterine cervical cancer patient treated by RT alone were: diarrhea (45.3%, p=0.008) and increased vaginal discharge (14.2%, p=0.029). The EORTC QLQ C-30 QoL items were significant better in OP+RT groups as comparison with RT alone group, including global health statues (p=0.043), cognitive function (p=0.033), social function (p=0.037), nausea/vomiting (p=0.027), pain(p=0.031), poor appetite (p=0.009) and financial problem (p=0.009). Constipation was worse significantly in OP+RT group than in RT alone group (p=0.002). Our study provided comparison and analysis of long-term QoL and side effects in early stage uterine cervical cancer patients treated by different modalities. These data were helpful for clinical physician not only for selecting treatment modalities when concerning with QoL of the patients, but also for rehabilitation and supportive care of the patients after treatment.