砷暴露地區居民發炎因子基因多形性與頸動脈粥狀硬化之相關性

The Association between Carotid Atherosclerosis and Inflammatory Gene Polymorphisms Among Residents in an Arsenic-Endemic Area

10.6288/TJPH2005-24-01-06

謝宜蓁(Yi-Chen Hsieh)；洪啟宗(Chi-Tzong Hong)；王淵宏(Yuan-Hung Wang)；陳建仁(Chien-Jen Chen)；邱弘毅(Hung-Yi Chiou)

砷 ； 頸動脈粥狀硬化 ； 細胞激素 ； 化學激素 ； 黏附因子 ； arsenic ； carotid atherosclerosis ； cytokine ； chemokine ； adhesion molecule

台灣公共衛生雜誌

24卷1期（2005 / 02 / 01）

64 - 72

繁體中文

Objectives: To investigate the association between carotid atherosclerosis and genetic polymorphisms of inflammatory genes among residents in the Lanyan Basin which was a newly confirmed arsenic-endemic area. Methods: Residents aged ≥40 years were recruited and examined for carotid atherosclerosis by Duplex ultrasonography. A total of 332 subjects were randomly selected from the study population as carotid atherosclerosis patients based on their health examination reports with IMT≥1.0 mm and a plaque score ≥1. Controls were 302 subjects with IMT＜l.0 mm and a plaque score＜1. Genetic polymorphisms of IL-1RN, TNF-α, MCP-1, E-selectin, and ICAM-1 were detected by PCR and RFLP. Results: After adjustment for age, sex, tobacco smoking, systolic blood pressure and total cholesterol, the study subjects whose inflammatory gene with variant genetic type have non-significant increased risk for development of carotid atherosclerosis. For study subjects who drank well-water with an arsenic concentration lower than 50μg/L, those who with MCP-1 GIG genotype have a four-fold risk of carotid atherosclerosis than those who with A/A genotype after adjusting the carotid atherosclerosis related risk factors. However, the risk can not be found for study subjects who drank well-water with an arsenic concentration greater than 50μg/L. Conclusions: The study suggested that the arsenic exposure had more significant influence on carotid atherosclerosis than on human susceptibility.

Objectives: To investigate the association between carotid atherosclerosis and genetic polymorphisms of inflammatory genes among residents in the Lanyan Basin which was a newly confirmed arsenic-endemic area. Methods: Residents aged ≥40 years were recruited and examined for carotid atherosclerosis by Duplex ultrasonography. A total of 332 subjects were randomly selected from the study population as carotid atherosclerosis patients based on their health examination reports with IMT≥1.0 mm and a plaque score ≥1. Controls were 302 subjects with IMT＜l.0 mm and a plaque score＜1. Genetic polymorphisms of IL-1RN, TNF-α, MCP-1, E-selectin, and ICAM-1 were detected by PCR and RFLP. Results: After adjustment for age, sex, tobacco smoking, systolic blood pressure and total cholesterol, the study subjects whose inflammatory gene with variant genetic type have non-significant increased risk for development of carotid atherosclerosis. For study subjects who drank well-water with an arsenic concentration lower than 50μg/L, those who with MCP-1 GIG genotype have a four-fold risk of carotid atherosclerosis than those who with A/A genotype after adjusting the carotid atherosclerosis related risk factors. However, the risk can not be found for study subjects who drank well-water with an arsenic concentration greater than 50μg/L. Conclusions: The study suggested that the arsenic exposure had more significant influence on carotid atherosclerosis than on human susceptibility.

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