1997年至1999年臺灣地區孩童上呼吸道感染單純疱疹病毒分析

Epidemiology of Upper Respiratory Infection Due to Herpes Simplex Virus Type 1 in Children in Taiwan During 1997-1999

10.6288/TJPH2002-21-05-08

吳秀玲(Shiow-Ling Wu)；王貞仁(Jen-Ren Wang)；陳宏一(Hong-I Chen)；呂立群(Li-Chun Lu)；陳豪勇(Hour-Young Chen)；涂醒哲(Shing-Jer Twu)

單純疱疹病毒第一型 ； 十二歲以下病童 ； 上呼吸道感染 ； 流行病學資料 ； Herpes simplex virus type 1 ； children under twelve years ； upper respiratory infection ； epidemiological information

台灣公共衛生雜誌

21卷5期（2002 / 10 / 01）

380 - 386

繁體中文

目標：針對12歲以下病童，分析上呼吸道感染患者的單純疱疹病毒第一型檢出率。提供單純疱疹病毒第一型流行病學的基本資料，以了解台灣單純疱疹第一型病毒檢出率與月份、年齡、性別、及發病日的關係。方法：1997年1月1日至1996年6月30日期間，收集臺北、臺中及臺南三地區各級醫療院所，12歲以下病童，上呼吸道感染患者的咽喉拭子檢體。藉由MDCK及H292細胞進行病毒培養並以免疫螢光染色方法鑑定病毒。結果：檢體總數3473件，4.6%來自醫學中心，6.7%來自區域醫院，5.0%來自地區醫院，83.7%的檢體來自私人診所；844件病毒陽性檢體中116件為單純疱疹病毒第一型，平均檢出率為3.3%。不同規模醫療院所的檢出率並沒有顯著的差異，但是北、中及南區的檢出率不同。確定病例中，1至3歲的孩童所佔比例最高(5.0%)。單純疱疹病毒第一型全年都可能被分離出來，1998年8月和9月的檢出率分別為22.9%和11.8%較其他月份高。此外，於發病5日內採檢，不同發病日之檢出率並無差異。結論：臺灣地區急性上呼吸道感染病童受到單純疱疹病毒第一型感染佔有一定的比例，所以在傳染病防治系統上值得重視。

Objectives: The purpose of this study was to investigate the relation between isolation rate of herpes simplex virus type 1 (HSY-l) and season, age of the child, gender, and disease day and we intend to provide basic epidemiological information about children with respiratory infection caused . by HSV -1. Methods: From January 1997 to June 1999, throat swab specimens were collected from children under twelve years with suspected upper respiratory tract infection. Samples were I collected from medical centers, area hospitals, local hospitals and private clinics in Taipei, Taichung and Tainan. MDCK and H292 cells line were used for viral isolation; immunofluorescence stain was used to identify HSV-l. Results: A total of 3473 specimens were collected during this period. About 83.7% of the isolates were collected from private clinics, 6.7% from area hospitals, 5.0% from local hospitals and 4.6% from medical centers. There were 844 positive viral isolation including 116 cases of HSV-1. The average isolation rate of HSV -1was 3.3%. Isolation rates of August (22.9%) and September (11.8%) in 1998 were higher than the rest. Isolation rates between the hospitals of different accredited levels were similar. The age distribution of HSV -1 positive cases showed the patients between 1-3 years had the highest incidence rates (5.0%). The isolation rate between first day to fifth day after symptoms begun showed no significant differences. Conclusions: These results imply that HSV-1 plays an important role in causing acute respiratory infection in children. Infectious disease surveillance system should pay more attention to HSV-l.

1. (1995).Control of communicable diseases manual.USA:United book.
2. Ansar-Ahmed, S., Penhale, W. J., Talal, N.(1985).Sex hormones, immune responses, and autoimmune disease. Mechanism of sex hormone action.American Journal of Pathology,121
3. Barna, M., Komatsu, T., Bi, Z.(1996).Sex differences in susceptibility to viral infection of the central nervous system.Journal of Neuroimmunology,67(1)
4. Chew, F. T., Doraisingham, S., Ling, A. E.(1998).Seasonal trends of viral respiratory tract infections in the tropics.Epidemiology and Infection,121(1)
5. De Arruda, E. N., Hayden, F. G., McAuliffe, J. F.(1991).Acute respiratory viral infections in ambulatory children of urban northeast Brazil.Journal of Infectious Diseases,164(2)
6. Denny, F. W., Clyde, W. A.(1986).Acute lower respiratory tract infections in nonhospitalized children.The Journal of Pediatrics,108
7. Fong, C. K., Landry, M. L.(1991).Advantages of multiple cell culture systems for detection of mixed-virus infections.Journal of Virological Methods,33(3)
8. Glezen, W. P., Greenberg, S. B., Atmar, R. L.(2000).Impact of respiratory virus infections on persons with chronic underlying conditions.JAMA: The Journal of the American Medical Association,283(4)
9. Glezen, W. P., Paredes, A., Taber, L. H.(1980).Influenza in children.JAMA: The Journal of the American Medical Association,243(13)
10. Hazlett, D. T. G., Bell, T. M., Tukei, P. M.(1988).Viral etiology and epidemiology of acute respiratory infections in children in Nairobi, Kenya.The American Journal of Tropical Medicine and Hygiene,39(6)
11. Ho, M., Chen, E. R., Hsu, K. U.(1999).An epidemic of enterovirus 71 infection in Taiwan..The New England Journal of Medicine,341(13)
12. Homo-Delarche, F., Fitzpatrick, F., Christeff, N.(1991).Sex steroids, glucocorticoids, stress and autoimmunity.The Journal of Steroid Biochemistry and Molecular Biology,40(4-6)
13. Lina, B., Valette, M., Foray, S.(1996).Surveillance of community-acquired viral infections due to respiratory viruses in Rhone-Alpes (France) during winter 1994 to 1995.Journal of Clinical Microbiology,34(12)
14. Monto, A. S., Cavallaro, J. J.(1971).The Tecumseh study of respiratory illness. II. Patterns of occurrence of infection with repiratory pathogens, 1965-1969.American Journal of Epidemiology,94(3)
15. Murray, P. R., Rosenthal, K. S., Kobayashi, G. S.(1997).Medical Microbiology.Mosby, Inc..
16. Olson, L. C., Lexomboon, U., Sithisarn, P.(1973).The etiology of respiratory tract infections in a tropical country.American Journal of Epidemiology,97(1)
17. Riley, L. E.(1998).Herpes simplex virus.Seminars in Perinatology,22(4)
18. Steiner, I.(1996).Human herpes viruses latent infection in the nervous system.Immunological reviews,152
19. Tai, F. H., Ma, C. C.(1966).Virus isolation and identification from throats of patients with respiratory diseases, in Taipei, 1964.Chin Med J,13
20. Whitley, R. J.(1994).Herpesvirus infection.USA:Marcel Dekker INC Press.
21. Williams, B. G., Gouws, E., Bochi-Pinto, C.(2002).Estimates of world-wide distribution of child deaths from acute respiratory infections.The Lancet Infectious Diseases,2(1)
22. 王貞仁 Wang, Jen-Ren, Tsai, H. P., Chen, P. F.(2000).An outbreak of enterovirus 71 infection in Taiwan, 1998. II. Laboratory diagnosis and genetic analysis.Journal of Clinical Virology,17(2)
23. 行政院衛生署(1996)。衛生統計（二）生命統計。台北:行政院衛生署。
24. 林奏延 Lin, Tzou-Yien(1995)。台北地區呼吸道病毒之監視。中華民國感染症醫學會雜誌 The Journal of Infectious Diseases Society, R. O. C.，6(1)
25. 高全良 Kao, Chuan-Liang、 Lee, C. N.、 Lee, W. L.(1991)。1981至1990年間於臺大醫院由臨床檢體中分離單純?疹病毒與其分型之情形 Isolation and typing of herpes simplex virus from clinical specimens collected at National Taiwan University Hospital, 1981-1990。中華民國微生物及免疫學雜誌 Chinese Journal of Microbiology and Immunology，24(3)
26. 曾仁谷 Tseng, Ren-Ku、 陳豪勇 Chen, Hour-Young、 洪其璧 Hong, Chi-Byi(1996)。1983年至1993年間台北地區流行性感冒病毒之病毒株分佈狀況 Influenza Virus Strains Isolated from 1983 to 1993 in Taipei。中華公共衛生雜誌 Chinese Journal of Public Health，15(1)
27. 曾仁谷 Tseng, Ren-Ku, 陳豪勇 Chen, Hour-Young, 洪其璧 Hong, Chi-Byi(1996).Influenza virus infections in Taiwan from 1979 to 1995.Japanese Journal of Medical Science ＆ Biology,49(3)