题名

長期照顧機構中中風住民潛在不適當的藥物使用:使用Beers標準觀察的個案

并列篇名

Potentially inappropriate medication use among stroke residents of a long-term care facility: an observational case study using the Beers Criteria

DOI

10.6288/TJPH.202108_40(4).110049

作者

刑志彬(Chih-Pin Hsing);連嘉豪(Jia-Haur Lian);李仁愛(Jen-Ai Lee);樊雪春(Hsueh-Chun Fan);陳世銘(Shih-Ming Chen);賴誠斌(Cheng-Pin Lai);蔡宜樺(Yi-Hua Tsai)

关键词

Beers標準 ; 不當用藥情況 ; 中風 ; 長期照顧 ; 處方優化 ; Beers Criteria ; potentially inappropriate medication ; stroke ; long-term care ; deprescribing

期刊名称

台灣公共衛生雜誌

卷期/出版年月

40卷4期(2021 / 08 / 30)

页次

429 - 440

内容语文

繁體中文

中文摘要

目標:研究欲探索長期照顧機構罹患中風住民(≥ 65歲)在潛在不適當用藥之人口變項情形、藥品類項,以及處方優化的合作經驗。方法:本研究是個案研究法,對象為台北市某區域醫院附設長期照顧機構22位住民,使用前瞻性的橫斷式研究蒐集資料,包含有(一)長期照顧機構住民基本資料(性別、年齡、用藥種類)和(二)不適當用藥盛行率、介入用藥結果。結果:本研究參與對象的慢性疾病數以4種最多,處方用藥數則以6-10種居多,在潛在不適當用藥方面,以Quetiapine居多。在處方優化有15位住民用藥需與醫師討論處方優化事宜,所佔比例為68.2%。結論:本研究透過2019年的Beers標準,發現長期照顧機構罹患中風住民用藥狀況有其特殊性,醫師依據個別住民的特定情況,考量藥物使用之目的性、有效性、迫切性、劑量合理性等,建議採用醫師與藥師的合作模式,並搭配Beers標準為參考,以降低潛在不適當用藥與處方優化。

英文摘要

Objectives: The demographic variables and drug use of stroke residents (aged ≥ 65 years) in long-term care facilities were explored for potentially inappropriate medication use, and a cooperation model for prescription optimization was examined. Methods: A total of 22 residents of a regional hospital in Taipei City were included. Data on the following were collected through a prospective cross-sectional method: (1) basic information (sex, age, types of medication), (2) prevalence of potentially inappropriate medication use, and (3) results of the medication intervention. Results: The maximum number of chronic diseases of any participant was four. The participants used 6 to 10 prescribed medications. Quetiapine was the foremost potentially inappropriate medication. The medications of 15 residents (68.2% of the participants) required discussion with attending physicians for deprescribing. Conclusions: Using the Beers criteria, the study determined that the prescriptions and medications of stroke residents in a long-term care facility exhibited unique characteristics. Attending physicians consider factors including the purpose, effectiveness, urgency, and rationality of dosage according to the specific conditions of individual residents when making prescriptions. The adoption of a cooperation model between physicians and pharmacists is recommended, as is the use of the Beers criteria as a reference to reduce potentially inappropriate medications and to promote prescription optimization.

主题分类 醫藥衛生 > 預防保健與衛生學
醫藥衛生 > 社會醫學
参考文献
  1. 何秀玉, HY,羅美芳, MF(2019)。簡介老人藥品使用適當性之評估工具。護理雜誌,66,20-28。
    連結:
  2. American Geriatrics Society(2015).Beers Criteria Update Expert Panel. American Geriatrics Society 2015 updated Beers Criteria for potentially inappropriate medication use in older adults.J Am Geriatr Soc,63,2227-2246.
  3. American Geriatrics Society(2019).Beers Criteria Update Expert Panel. American Geriatrics Society 2019 updated AGS Beers Criteria for potentially inappropriate medication use in older adults.J Am Geriatr Soc,67,674-694.
  4. American Geriatrics Society(2012).Beers Criteria Update Expert Panel. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults.J Am Geriatr Soc,60,616-631.
  5. Beers, MH(1997).Explicit criteria for determining potentially inappropriate medication use by the elderly: an update.Arch Intern Med,157,1531-1536.
  6. Beers, MH,Ouslander, JG,Rollingher, I,Reuben, DB,Brooks, J,Beck, JC(1991).Explicit criteria for determining inappropriate medication use in nursing home residents.Arch Intern Med,151,1825-1832.
  7. Boult, C,Green, AF,Boult, LB,Pacala, JT,Snyder, C,Leff, B(2009).Successful models of comprehensive care for older adults with chronic conditions: evidence for the institute of medicine’s "retooling for an aging America" report.J Am Geriatr Soc,57,2328-2337.
  8. Chang, CB,Lai, HY,Hwang, SJ(2019).The updated PIM-Taiwan criteria: a list of potentially inappropriate medications in older people.Ther Adv Chronic Dis,10,2040622319879602.
  9. Chang, CB,Lai, HY,Yang, SY(2014).Patient and clinic visit-related factors associated with potentially inappropriate medication use among older home healthcare service recipients.PLoS One,9,e94350.
  10. Chang, CB,Yang, SY,Lai, HY(2012).Using published criteria to develop a list of potentially inappropriate medications for elderly patients in Taiwan.Pharmacoepidemiol Drug Saf,21,1269-1279.
  11. Clyne, B,Bradley, MC,Hughes, C,Fahey, T,Lapane, KL(2012).Electronic prescribing and other forms of technology to reduce inappropriate medication use and polypharmacy in older people: a review of current evidence.Clin Geriatr Med,28,301-322.
  12. Coleman, EA,Parry, C,Chalmers, S,Min, SJ(2006).The care transitions intervention: results of a randomized controlled trial.Arch Intern Med,166,1822-1828.
  13. Corrigan, JM,Nielsen, DM(1993).Toward the development of uniform reporting standards for managed care organizations: the Health Plan Employer Data and Information Set (Version 2.0).Jt Comm J Qual Improv,19,566-575.
  14. Corsonello, A,Pranno, L,Garasto, S,Fabietti, P,Bustacchini, S,Lattanzio, F(2009).Potentially inappropriate medication in elderly hospitalized patients.Drugs Aging,26(Suppl 1),31-39.
  15. Dedhiya, SD,Hancock, E,Craig, BA,Doebbeling, CC,Thomas, J(2010).Incident use and outcomes associated with potentially inappropriate medication use in older adults.Am J Geriatr Pharmacother,8,562-570.
  16. Fick, DM,Cooper, JW,Wade, WE(2003).Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts.Arch Intern Med,163,2716-2724.
  17. Frankenthal, D,Lerman, Y,Kalendaryev, E,Lerman, Y(2014).Intervention with the screening tool of older persons potentially inappropriate prescriptions/screening tool to alert doctors to right treatment criteria in elderly residents of a chronic geriatric facility: a randomized clinical trial.J Am Geriatr Soc,62,1658-1665.
  18. Gallacher, KI,Batty, GD,McLean, G(2014).Stroke, multimorbidity and polypharmacy in a nationally representative sample of 1,424,378 patients in Scotland: implications for treatment burden.BMC Med,12,151.
  19. Gallagher, PF,Barry, PJ,Ryan, C,Hartigan, I,O’Mahony, D(2008).Inappropriate prescribing in an acutely ill population of elderly patients as determined by Beers’ Criteria.Age Ageing,37,96-101.
  20. Garfinkel, D,Mangin, D(2010).Feasibility study of a systematic approach for discontinuation of multiple medications in older adults: addressing polypharmacy.Arch Intern Med,170,1648-1654.
  21. Heider, D,Matschinger, H,Meid, AD(2018).The impact of potentially inappropriate medication on the development of health care costs and its moderation by the number of prescribed substances. Results of a retrospective matched cohort study.PLoS One,13,e0198004.
  22. Holt, S,Schmiedl, S,Thürmann, PA(2010).Potentially inappropriate medications in the elderly: the PRISCUS list.Dtsch Arztebl Int,107,543-551.
  23. Jano, E,Aparasu, RR(2007).Healthcare outcomes associated with beers’ criteria: a systematic review.Ann Pharmacother,41,438-447.
  24. Leikola, S,Dimitrow, M,Lyles, A,Pitkälä, K,Airaksinen, M(2011).Potentially inappropriate medication use among Finnish non-institutionalized people aged ≥ 65 years.Drugs Aging,28,227-236.
  25. Lin, YJ,Peng, LN,Chen, LK,Lin, MH,Hwang, SJ(2011).Risk factors of potentially inappropriate medications among older patients visiting the community health center in rural Taiwan.Arch Gerontol Geriatr,53,225-228.
  26. Mestres, C,Agustí, A,Puerta, L,Barba, M(2015).Prescription of potentially inappropriate drugs for geriatric patients in long-term care: improvement through pharmacist’s intervention.Eur J Hosp Pharm,22,198-201.
  27. Midlöv, P,Bahrani, L,Seyfali, M,Höglund, P,Rickhag, E,Eriksson, T(2012).The effect of medication reconciliation in elderly patients at hospital discharge.Int J Clin Pharm,34,113-119.
  28. Morgan, SG,Hunt, J,Rioux, J,Proulx, J,Weymann, D,Tannenbaum, C(2016).Frequency and cost of potentially inappropriate prescribing for older adults: a crosssectional study.CMAJ Open,4,E346-E351.
  29. Naugler, CT,Brymer, C,Stolee, P,Arcese, ZA(2000).Development and validation of an improving prescribing in the elderly tool.Can J Clin Pharmacol,7,103-107.
  30. Nothelle, SK,Sharma, R,Oakes, AH,Jackson, M,Segal, JB(2017).Determinants of potentially inappropriate medication use in long-term and acute care settings: a systematic review.J Am Med Dir Assoc,18,806.e1-806.e17.
  31. O‘Mahony, D,O’Sullivan, D,Byrne, S,O’Connor, MN,Ryan, C,Gallagher, P(2015).STOPP/START criteria for potentially inappropriate prescribing in older people: version 2.Age Ageing,44,213-218.
  32. Onder, G,Pedone, C,Landi, F(2002).Adverse drug reactions as cause of hospital admissions: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA).J Am Geriatr Soc,50,1962-1968.
  33. Perri, M, 3rd,Menon, AM,Deshpande, AD(2005).Adverse outcomes associated with inappropriate drug use in nursing homes.Ann Pharmacother,39,405-411.
  34. Quinalha, JV,Cassyano, JC(2010).Tools for assessing the pharmacotherapy of the elderly: a review.Rev Bras Geriatr Gerontol,13,487-499.
  35. Reeve, E,Gnjidic, D,Long, J,Hilmer, S(2015).A systematic review of the emerging definition of ‘deprescribing’ with network analysis: implications for future research and clinical practice.Br J Clin Pharmacol,80,1254-1268.
  36. Reilly, T,Barile, D,Reuben, S(2012).Role of the pharmacist on a general medicine acute care for the elderly unit.Am J Geriatr Pharmacother,10,95-100.
  37. Scott, IA,Pillans, PI,Barras, M,Morris, C(2018).Using EMRenabled computerized decision support systems to reduce prescribing of potentially inappropriate medications: a narrative review.Ther Adv Drug Saf,9,559-573.
  38. Sergi, G,Rui, MD,Sarti, S,Manzato, E(2011).Polypharmacy in the elderly.Drugs Aging,28,509-518.
  39. Wang, TC,Trezise, D,Ku, PJ,Lu, HL,Hsu, KC,Hsu, PC(2019).Effect of pharmacist intervention on a population in Taiwan with high healthcare utilization and excessive polypharmacy.Int J Environ Res Public Health,16,2208.
  40. Yang, PJ,Lee, YT,Tzeng, SL(2015).Potentially inappropriate prescribing in disabled older patients with chronic diseases: a screening tool of older persons’ potentially inappropriate prescriptions versus Beers 2012 Criteria.Med Princ Pract,24,565-570.
  41. Zhan, C,Sangl, J,Bierman, AS(2001).Potentially inappropriate medication use in the community-welling elderly.JAMA,286,2823-2829.
  42. 內政部:104年第3週內政統計通報,2015。http://www.moi.gov.tw。引用2020/07/31。 Ministry of the Interior, R.O.C. (Taiwan). 2015: 3rd Ministry of the statistical report. Available at: http://www.moi.gov.tw. Accessed July 31, 2020. [In Chinese]
  43. 內政部:內政統計通報,2017。http://sowf.moi.gov.tw/stat/week/week10610.pdf。引用2020/07/31。 Ministry of the Interior, R.O.C. (Taiwan). Bulletin of interior statistics, 2017. Available at: http://sowf.moi.gov.tw/stat/week/week10610.pdf . Accessed July 31, 2020. [In Chinese]
  44. 吳承誌, CC,張鐳, LU(2013)。老人用藥評估工具—STOPP & START介紹。藥學雜誌,29,110-114。
  45. 杜彗寧, HN,張家銘, CM,周玟觀, WK,葉鳳英, PY(2017)。老年人之用藥問題。台灣老年醫學暨老年學雜誌,12,1-19。
  46. 翁茂中, MC(2017)。台中=Taichung,中山醫學大學醫學研究所=Institute of Medicine, Chung Shan Medical University。
  47. 陳姿吟, TY,李季黛, CT,周明岳, MY,薛光傑, KC,杜明勳, MS(2011)。簡介老人用藥準則之工具。家庭醫學與基層醫療,26,370-376。