勞工健檢常見成人無症狀未接合型高膽紅素血症之盛行率及相關因子探討

Prevalence of Asymptomatic Unconjugated Hyperbilirubinemia among Adult in Workplace

10.30027/CJOM.200707.0003

周川宏(Chung-Hung Chou)；黃建元(Chien-Yuan Huang)；蘇世斌(Shih-Bin Su)；林勤益(Ching-Yih Lin)；邱千芳(Chien-Fang Chiu)

無症狀未結合型高膽紅素血症 ； Gilbert's syndrome ； 勞工健檢 ； unconjungated hyperbilirubinemia ； Gilbert's syndrome

中華職業醫學雜誌

14卷3期（2007 / 07 / 01）

161 - 170

繁體中文

Objectives: Unconjugated bilirubin is present in small amounts in normal serum and is increased in several hematologic disease and hepatic disorders. The prevalence of asymptomatic unconjungated hyperbilirubinemia occurs in about 2-12% in western population. But the data in Taiwan is rare. So, we conducted a study to survey the prevalence of unconjungated hyperbilirubinemia and discussed the article. Methods: The patients here who worked over six months were included, except for those with: (1) HBV or HCV; (3) gallstones. The data on demographic characteristics and standard methods-measured biochemical variables (total bilirubin, direct bilirubin, GPT, HBsAg and anti-HCV) were collected before analyzed by SPSS Ver.12.0. Results: The 11831 persons in the voluntary health examination were: 1306 HBV carriers and 30 HCV carriers (among whom, 2 with HBV and HCV). There were 10497 participants enrolled herein. The overall prevalence of aymptomatic unconjungated hyperbilirubinemia was 3.86%; therefore, the sex (male) was related to the said disease (male 5.4% vs. female 2.8%, p＜0.001). After the interactive factors adjusted, the sex (male) remained related to the just-mentioned disease. Conclusion: Asymptomatic unconjugated bilirubinemia is not rare in local clinics, and is usually caused by Gilbert syndrome. Diagnostically, caloric restriction test, nicotinic acid test, and rifampin test were more convenient, non-invasive than gene screen and liver biopsy.

Objectives: Unconjugated bilirubin is present in small amounts in normal serum and is increased in several hematologic disease and hepatic disorders. The prevalence of asymptomatic unconjungated hyperbilirubinemia occurs in about 2-12% in western population. But the data in Taiwan is rare. So, we conducted a study to survey the prevalence of unconjungated hyperbilirubinemia and discussed the article. Methods: The patients here who worked over six months were included, except for those with: (1) HBV or HCV; (3) gallstones. The data on demographic characteristics and standard methods-measured biochemical variables (total bilirubin, direct bilirubin, GPT, HBsAg and anti-HCV) were collected before analyzed by SPSS Ver.12.0. Results: The 11831 persons in the voluntary health examination were: 1306 HBV carriers and 30 HCV carriers (among whom, 2 with HBV and HCV). There were 10497 participants enrolled herein. The overall prevalence of aymptomatic unconjungated hyperbilirubinemia was 3.86%; therefore, the sex (male) was related to the said disease (male 5.4% vs. female 2.8%, p＜0.001). After the interactive factors adjusted, the sex (male) remained related to the just-mentioned disease. Conclusion: Asymptomatic unconjugated bilirubinemia is not rare in local clinics, and is usually caused by Gilbert syndrome. Diagnostically, caloric restriction test, nicotinic acid test, and rifampin test were more convenient, non-invasive than gene screen and liver biopsy.