Osmotic Demyelination Syndrome Following Oral Sodium Phosphate Solution Administration for Colon Preparation: A Case Report and Literature Review

Hsiu-Li Wu；Chen-Chun Lin

central pontine myelinolysis ； osmotic demyelination syndrome ； hyperphosphatemia

胸腔醫學

39卷3期（2024 / 09 / 01）

256 - 261

英文

Osmotic demyelination syndrome (ODS) is a rare neurological disorder characterized by non-inflammatory demyelination of the pons. Etiological factors for ODS include rapid correction of hyponatremia, alcoholism, hypertonic or hypotonic syndrome, acquired immunodeficiency syndrome, liver transplantation, refeeding syndrome, and electrolyte imbalances. In this report, we present the case of an elderly individual who fell into a coma following ingestion of 90 ml of oral sodium phosphate solution for colon preparation prior to colonoscopy. Brain magnetic resonance imaging and laboratory data analysis confirmed the diagnosis of ODS, with hyperphosphatemia identified as a contributing factor. A comprehensive literature review was conducted to explore the underlying mechanisms and risk factors for ODS.