Oncocytic Carcinoma of the Submandibular Gland, from Benign to Malignant-A Report on an Unusual Case

頜下腺嗜酸細胞癌，從良性轉向惡性：一病列報告

10.6316/TRO/201017(2)161

郭珍妮(Jenny Que)；林立青(Li-Ching Lin)；李文瑛(Wen-Ying Lee)；林奎利(Kue-Li Lin)；林佳輝(Chia-Hui Lin)；林裕爲(Yu-Wei Lin)；楊清傑(Ching-Chieh Yang)

嗜酸細胞癌 ； 頜下腺 ； 放射治療 ； Oncocytic carcinoma ； Submandibular gland ； Radiotherapy

放射治療與腫瘤學

17卷2期（2010 / 06 / 01）

161 - 167

英文

目的：嗜酸細胞瘤是一個非常罕見的腫瘤,通常是良性的，一般發生在腮腺。嗜酸細胞癌更是少見的，其中包括大約只有5%的所有嗜酸細胞瘤。在嚴謹的審查，世界文學，只有少數案件的頜下腺嗜酸細胞癌的報導，更不尋常的是它以前所產生的良性嗜酸細胞瘤。我們描述一個額外案件頜下腺嗜酸細胞瘤向惡性轉化與區域淋巴結轉移。 病人與方法：一例罕見的51歲男子惡性嗜酸細胞瘤是。腫瘤被發現在左頜下腺與區域淋巴結腫大。 結果和結論：嗜酸細胞癌似乎產生於良性嗜酸細胞，或者也可能是原發腫瘤。頭頸部嗜酸細胞癌，是否存在轉移，而不是局部淋巴結轉移是最重要的預後指標。治療包括手術切除和放射治療，但放射治療的療效以及化療仍不清楚。

Purpose: Oncocytomas are very rare tumors that are usually benign and typically occur in the parotid gland. Oncocytic carcinomas are even more uncommon, comprising only approximately 5% of all oncocytomas. In a critical review of the international medical literature, only a few cases of oncocytic carcinoma of submandibular gland were found. Even more unusual was the fact in this case, it arose from a previously benign oncocytoma. We describe this case of submandibular oncocytoma transforming into a malignancy associated with regional lymph node metastases. Patient and Methods: A rare case of 51 year-old man with malignant oncocytoma is presented. The tumor was found in the left submandibular gland with regional lymph node enlargement. Results and Conclusion: Oncocytic carcinoma appears to arise from benign oncocytomas, or may also arise de novo. In oncocytic carcinoma of the head and neck, the presence of distant, rather than local lymph node, metastasis is the most important prognostic indicator. Therapy consists of surgical resection and radiotherapy but the efficacy of radiotherapy, and chemotherapy are still unclear.