二週運動減肥對女性肥胖基因(ob gene)表現之影響

Effects of Two-Week Weight Reduction by Exercise on Women OB Gene Expression

10.6222/pej.0023.199709.3120

劉建恒(Chien-Heng Liu)；周芬碧(Fun-Pi Chou)；李水碧(Shuei-Pi lee)；李祖遠(Tzuu-Yeuan Lee)；方進隆(Chin-Lung Fand)

運動減肥 ； 肥胖基因 ； 瘦身蛋白 ； exercise ； weight reduction ； OB gene ； obese protein ； leptin

體育學報

23期（1997 / 09 / 01）

227 - 238

繁體中文

It has been reported that using diet to reduce weight repressed the expression of obese gene, which consequently caused loss of control of appetite, and failed the program. In this study exercise was employed to investigate its effect on obese protein level, trying to distingugish the difference between the outcomes of weight reduction by diet and by exercise. Seven female subjects were given a weight-reduction plan composed of 6hr bicycling every day for consecutive 2 weeks for total distance 1200 km. Blood samples were taken at the 1st, 8th, and 15th days and analyzed for the plasma level of leptin, product of OB gene. The changes in weight, body mass index (BMI) and skinfolds were also recorded. The following results obtained: (1) After two weeks of exercise, the averages of weight, BMI and the total thickness skin fold taken from 5 different body parts were significantly (P＜0.05) reduced by 4.2±0.3kg (7.4%), 1.5±0.3 (6.8%) and 61.5±5.1mm (50.8%) repectively, (2)The expressions of OB gene were markedly different between two consecutive sample drawing points (P＜0.05), though no difference was observed between the first and the last sample. The results of present study showed that during the exercise training the leptin levels of the subjects did not decrease along with the reduction of body fat, distinctly different from the data achieved from the diet study. This indicates that exercise training might be a better way to reduce weight than limiting intake of food by avoiding influence on the OB gene expression, and preventing losing control of appetite. For long term maintenance of body weight exercise also seems a better choice, though the mechanism of its effect on leptin will need further investigation.

It has been reported that using diet to reduce weight repressed the expression of obese gene, which consequently caused loss of control of appetite, and failed the program. In this study exercise was employed to investigate its effect on obese protein level, trying to distingugish the difference between the outcomes of weight reduction by diet and by exercise. Seven female subjects were given a weight-reduction plan composed of 6hr bicycling every day for consecutive 2 weeks for total distance 1200 km. Blood samples were taken at the 1st, 8th, and 15th days and analyzed for the plasma level of leptin, product of OB gene. The changes in weight, body mass index (BMI) and skinfolds were also recorded. The following results obtained: (1) After two weeks of exercise, the averages of weight, BMI and the total thickness skin fold taken from 5 different body parts were significantly (P＜0.05) reduced by 4.2±0.3kg (7.4%), 1.5±0.3 (6.8%) and 61.5±5.1mm (50.8%) repectively, (2)The expressions of OB gene were markedly different between two consecutive sample drawing points (P＜0.05), though no difference was observed between the first and the last sample. The results of present study showed that during the exercise training the leptin levels of the subjects did not decrease along with the reduction of body fat, distinctly different from the data achieved from the diet study. This indicates that exercise training might be a better way to reduce weight than limiting intake of food by avoiding influence on the OB gene expression, and preventing losing control of appetite. For long term maintenance of body weight exercise also seems a better choice, though the mechanism of its effect on leptin will need further investigation.