题名

血管張力素轉化酶及α-輔肌動蛋白基因與運動表現之關係

DOI

10.6223/qcpe.2003.200609.1504

作者

張鵬遠;徐台閣

关键词

血管張力素轉化酶 ; α-輔肌動蛋白 ; 基因多型性 ; 運動表現

期刊名称

中華體育季刊

卷期/出版年月

20卷3期(2006 / 09 / 01)

页次

28 - 35

内容语文

繁體中文

中文摘要

愈來愈多的研究顯示:與心血管及肌肉功能相關的基因對運動表現有一定程度影響。其中研究較多的有:血管張力素轉化酶(angiotensin converting enzyme, ACE)基因及α-輔肌動蛋白3(α-Actinin 3; ACTN3)基因。不同形態的運動選手,其基因特性也不同。肌力型運動員其血管張力素轉化酶基因多呈刪除型,而α-輔肌動蛋白3基因多呈野生型(wild type,指未經突變之型式)。耐力型運動員其血管張力素轉化酶基因多呈嵌入型,而α-輔肌動蛋白基因多呈突變型(null type)。本文綜合了多篇探討血管張力素轉化酶基因或α-輔肌動蛋白基因與運動表現的文獻,以回溯方式整理,期望能提供讀者一些有用的資訊。

主题分类 社會科學 > 體育學
参考文献
  1. Bloem, L. J.,Manatunga, A. K.,Pratt, J. H.(1996).Racial difference in the relationship of an angiotensin I-converting enzyme gene polymorphism to serum angiotensin I-converting enzyme activity.Hypertension,27(1),62-66.
  2. Clarkson, P. M.,Devaney, J. M.,Gordish-Dressman, H.,Thompson, P. D.,Hubal, M. J.,Urso, M.(2005).ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women.Journal of Applied Physiology,99(1),154-163.
  3. Clarkson, P. M.,Hoffman, E. P.,Zambraski, E.,Gordish-Dressman, H.,Kearns, A.,Hubal, M.(2005).ACTN3 and MLCK genotype associations with exertional muscle damage.Journal of Applied Physiology,99(2),564-569.
  4. Danser, A. H.,Schalekamp, M. A.,Bax, W. A.,van den Brink, A. M.,Saxena, P. R.,Riegger, G. A.(1995).Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism.Circulation,92(6),1387-1388.
  5. Folland J.,Leach, B.,Little, T.,Hawker, K.,Myerson, S.,Montgomery, H.(2000).Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload.Experimental Physiology,85(5),575-579.
  6. Gayagay, G.,Yu, B.,Hambly, B.,Boston, T.,Hahn, A.,Celermajer, D. S.(1998).Elite endurance athletes and the ACE I allele--the role of genes in athletic performance.Human Genetics,103(1),48-50.
  7. Geisterfer, A. A.,Peach, M. J.,Owens, G. K.(1988).Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.Circulation Research,62(4),749-756.
  8. Heled, Y.,Moran, D. S.,Mendel, L.,Laor, A.,Pras E.,Shapiro Y.(2004).Human ACE I/D polymorphism is associated with individual differences in exercise heat tolerance.Journal of Applied Physiology,97(1),72-76.
  9. Hopkinson, N. S.,Nickol, A. H.,Payne, J.,Hawe, E.,Man, W. D.,Moxham. J.(2004).Angiotensin converting enzyme genotype and strength in chronic obstructive pulmonary disease.American Journal of Respiratory Critical Care Medicine,170(4),395-399.
  10. Kanazawa, H.,Hirata, K.,Yoshikawa, J.(2003).Influence of oxygen administration on pulmonary haemodynamics and tissue oxygenation during exercise in COPD patients with different ACE genotypes.Clinical Physiology and Functional Imaging,23(6),332-336.
  11. Kanazawa, H.,Tateishi, Y.,Yoshikawa, J.(2004).Acute effects of nifedipine administration in pulmonary haemodynamics and oxygen delivery during exercise in patients with chronic obstructive pulmonary disease: Implication of the angiotensin-converting enzyme gene polymorphisms.Clinical Physiology and Functional Imaging,24(4),224-228.
  12. Mills, M.,Yang, N.,Weinberger, R.,Vander Woude, D. L.,Beggs, A. H.,Easteal, S.(2001).Differential expression of the actin-binding proteins, -actinin-2 and -3, in different species: Implications for the evolution of functional redundancy.Human Molecular Genetics,10(13),1335-1346.
  13. Montgomery, H. E.,Marshall, R.,Hemingway, H.,Myerson, S.,Clarkson, P.,Dollery, C.(1998).Human gene for physical performance.Nature,393(6682),221-222.
  14. Nazarov, I. B.,Woods, D. R.,Montgomery, H. E.,Shneider, O. V.,Kazakov, V. I.,Tomilin, N. V.(2001).The angiotensin converting enzyme I/D polymorphism in Russian athletes.European Journal of Human Genetics,9(10),797-801.
  15. North, K. N.,Yang, N.,Wattanasirichaigoon, D.,Mills, M.,Easteal, S.,Beggs A. H.(1999).A common nonsense mutation results in alpha-actinin-3 deficiency in the general population.Nature Genetics,21(4),353-354.
  16. Rankinen, T.,Perusse, L.,Rauramaa, R.,Rivera, M.,Wolfarth, B.,Bouchard, C.(2001).The human gene map for performance and health-related fitness phenotypes.Medicine and Science in Sports and Exercise,33(6),855-867.
  17. Rigat, B.,Hubert, C.,Alhenc-Gelas, F.,Cambien, F.,Corvol, P.,Soubrier, F.(1990).An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.Journal of Clinical Investigation,86(4),1343-1346.
  18. Rigat, B.,Hubert, C.,Corvol, P.,Soubrier, F.(1992).PCR detection of the insertion/ deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1).Nucleic Acids Research,20(6),1433.
  19. Simonean, J. A.,Bonchard, C.(1995).Genetic determinism of fiber type proportion in human skeletal muscle.Federation of merican ocieties for Experimental Biology Journal,9,1091-1095.
  20. Woods, D.,Hickman, M.,Jamshidi, Y.,Brull, D.,Vassiliou, V.,Jones, A.(2001).Elite swimmers and the D allele of the ACE I/D polymorphism.Human Genetics,108(3),230-232.
  21. Yang, N.,MacArthur, D. G.,Gulbin, J. P.,Hahn, A. G.,Beggs, A. H.,Easteal, S.(2003).ACTN3 genotype is associated with human elite athletic performance.American Journal of Human Genetics,73(3),627-631.
  22. Zhang, B.,Tanaka, H.,Shono, N.,Miura, S.,Kiyonaga, A.,Shindo, M.(2003).The I allele of the angiotensin-converting enzyme gene is associated with an increased percentage of slow-twitch type I fibers in human skeletal muscle.Clinical Genetics,63(2),139-144.
  23. Zhao, B.,Moochhala, S. M.,Tham, S.,Lu, J.,Chia, M.,Byrne, C.(2003).Relationship between angiotensin-converting enzyme ID polymorphism and VO2max of Chinese males.Life Sciences,73(20),2625-3630.
  24. 朱雲瑋、蔡淳淳、曾慶宗、胡虞國譯、David, P. C.、Lonnie, D. R.(2004)。分子生物學-輕輕鬆鬆學分生。臺北縣:藝軒。
  25. 科學月刊
  26. 樓迎統、陳君侃、黃榮棋、王錫五(2002)。實用生理學。臺北市:偉華。
被引用次数
  1. 陳全壽(2014)。追求卓越的運動表現。運動表現期刊,1(1),1-5。
  2. 孫佳婷(2021)。基因科技/基因禁藥研究:臺灣運動領域之認識架構。運動教練科學,61,41-51。
  3. 孫佳婷(2021)。基因與細胞禁藥治理-一個STS取向的考察。運動文化研究,39,33-78。
  4. 張鵬遠、徐台閣、毛彥明(2007)。血管張力素轉化酶基因與優秀跆拳道選手之關係。體育學報,40(3),29-38。