運動對骨骼肌誘發細胞凋亡訊息傳遞路徑的影響

10.6223/qcpe.2203.200809.1702

陳聰毅

運動 ； 骨骼肌 ； 細胞凋亡

中華體育季刊

22卷3期（2008 / 09 / 01）

8 - 15

繁體中文

正常細胞或組織之細胞凋亡訊息傳遞路徑可區分爲粒腺體、內質網及死亡訊息等三條主要路徑。雖研究顯示運動會增加骨骼肌細胞凋亡的現象，但其誘發之機轉仍不清楚，故本文旨在於探討運動對骨骼肌細胞凋亡之誘發因子的影響。粒腺體路徑可能是因運動改變粒腺體外膜之通透性，而使細胞素c、第二粒腺體衍生劊蛋白活化子／低等電點細胞凋亡結合蛋白直接抑制子及細胞凋亡誘發因子的釋出量增加，進而活化下游之劊蛋白酶徑路而增加細胞凋亡現象。內質網路徑主要可能是因運動導致細胞內鈣離子濃度增加之故。死亡訊息路徑主要可能爲運動改變細胞外腫瘤壞死因子α的濃度有關，故不同運動型式可能誘發不同之訊息傳遞路徑，而導致骨骼肌不同程度之細胞凋亡現象。

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