低氧環境與氧化壓力

10.6223/qcpe.2301.200903.1601

陸康豪；謝伸裕；林嘉志

活性氧 ； 氧化壓力 ； 低氧 ； 低氧再充氧

中華體育季刊

23卷1期（2009 / 03 / 01）

1 - 9

繁體中文

激烈運動可產生過量的活性氧化物(reactive oxygen species, ROS)，並破壞人體內氧化壓力與抗氧化系統間的平衡關係，對細胞、組織造成累積性的氧化傷害，而低氧環境已被證實爲誘導人體產生ROS的刺激源。研究證據顯示人體或動物在低氧環境下，血液或骨骼肌等部位脂質過氧化指標（如：TBARS）、蛋白質氧化傷害指標（如：羰基化蛋白質）及氧化態/還原態麩胱甘肽（如：GSSG/GSH）比例均隨著氧氣分壓的下降而增加，而超氧離子歧化酶活性則會下降。因此，不論是進行攀登高山活動或是運動員進行高地訓練時，除了要注意高山症之外，也不能忽視ROS造成的氧化壓力。此外，由低氧再回復到常氧環境時，紅血球與肌肉的氧化壓力也會顯著增加。暴露於低氧環境時，服用適量的抗氧化劑可能有助於清除體內的ROS，減緩人體所承受的氧化壓力。

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