運動對血管新生幹細胞調動的影響

10.6223/qcpe.2402.201006.2003

林勁宏

內皮前驅細胞 ； 血管新生作用 ； 血管內皮生長因子

中華體育季刊

24卷2期（2010 / 06 / 01）

20 - 28

繁體中文

近幾年來科學家開始注意由幹細胞所分化成的內皮前驅細胞，具有修復組織及血管新生的能力，但幹細胞要能參與血管的新生作用，首要步驟是要從骨髓中被調動，進入血液循環中，其調動作用除受細胞激素刺激外，運動也是其中之一的方式。單次的運動刺激通常需要較高強度的運動負荷或運動量，才能顯著增加血管新生幹細胞的數量，但老年者如在相同的運動刺激下，卻有負面的效果。而罹患血管阻塞者或老年者經長期運動訓練增加內皮前驅細胞的效果比健康者來得明顯。目前認爲運動促使血管內皮生長因子及血管中的剪力作用增加是調動幹細胞主因。雖然運動已被證明能增加內皮前驅細胞，但不同的運動條件或相異環境下運動，對幹細胞的影響程度仍然不是很明瞭。

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