可控制奈米微粒產生技術開發

Development of Controllable a Nanoparticle Generation Technique

10.7005/JOSH.200906.0153

李曜全(Yao-Chuan Lee)；林文印(Wen-Yinn Lin)；鄭福田(Fu-Tien Jeng)

奈米微粒 ； 氣膠產生 ； 蒸發／冷凝 ； Nanoparticle ； Aerosol generation ； Evaporation/condensation

勞工安全衛生研究季刊

17卷2期（2009 / 06 / 01）

153 - 174

繁體中文

為進行奈米微粒人體健康危害相關評估工作，以特定方法產生穩定之測試用奈米微粒，為模擬環境中實際奈米微粒的主要方法，不論模擬呼吸道沉積實驗或動物毒性實驗等方法均需應用該項微粒產生技術。 由於各類型污染源所產生奈米微粒因微粒形成方式之不同各有不同之外形結構，這些奈米微粒因而具有不同之粒徑或表面積特性，造成微粒粒徑或表面積大小不同之差異將可能造成微粒對人體毒性之重大影響，本研究主要目標即在研發一套能夠控制粒徑之奈米微粒產生系統，所產製之微粒粒徑在10-100奈米範圍內，以模擬各類不同作業場所可能發生之實際奈米微粒環境，可用於評估各類環境控制設施、個人防護具效率或動物毒性實驗所需穩定之測試微粒來源及相關研究之推展。 本研究建立一套冷凝式電熱陶瓷管氣膠產生器微粒粒徑產生系統，經性能測試後提出最佳儀器設計系統、控制操作條件，以及該系統之穩定性，利用所產生之奈米銀微粒試行奈米微粒粒徑與表面積測試，並產生不同膠結程度之奈米微粒，以提供毒性測試。

The generation of stable nanoparticles to simulate the samp in the environment is a primary step in evaluating the effects of nanoparticles on human health. It is also used in simulation of respiratory tract deposition and the toxicity of inhaled nanostructured particles. Therefore, nanoparticle generation is an essential technique in research on nanoparticles from a health perspective. Nanoparticles generated by various sources may have different morphologies, particle size, and surface area. The particle size. and surface area are both important factors in determining the toxicity of inhaled nanoparticles. This research project aimed to develop a controllable nanoparticle generating system to support nanoparticle-related research with a stable sample source. To provide for research on the impact of nanoparticles on health, a generating system was developed to generate particles of 10 to 100 nanometers in diameter to simulate samples from various environmental sources. In this project, a condensation-type aerosol generator consisting of an electrically heated ceramic tube generating system was developed and tested to obtain optimal operating conditions and stability. The generated nanoparticles of different sintering condition can be used for research on the toxicity of different particle sizes and surface areas.