健身器材製造業勞工職業暴露與健康傷害之研究

Determinations of Occupational Exposures and Health Effects from the Workers of Industries for Producing Fitness Equipments

陳秀玲(Hsiu-Ling Chen)；吳宜蓁(Yi-Chen Wu)；劉冠岑(Kuan-Tsen Liu)；林洺秀(Ming-Hsun Lin)

健身器材 ； 氧化性傷害 ； 重金屬 ； 染色體端粒 ； Fitness equipments ； Oxidative damage ； Metals ； TNF-α

勞工安全衛生研究季刊

22卷2期（2014 / 06 / 01）

136 - 146

繁體中文

運動器材製造過程包含器具切割、噴漆、銲接、零件組裝、拋光、品管等，其中以銲接作業與噴漆為主要之工作型態，包含金屬粉塵、活性含氧物種（Reactive Oxygen Species, ROS）等。本研究以外銷健身器材之製造公司為主要研究場所，進行作業環境空氣重金屬與ROS濃度之評估。另亦進行健身器材作業勞工之生物暴露偵測，如分析血液重金屬；勞工之生物效應偵測則評估氧化傷害（Malondialdehyde, DNA Srand Beaks（Tail Moment），染色體端粒長度（Telomere Length, TL）、肺部發炎指標（Tumor Necrosis Factor-α, TNF-α）及心血管疾病指標（High Sensitivity C-reactive Protein, hs-CRP）之評估。結果顯示ROS濃度結果以銲接區濃度為最高，噴漆區次之；重金屬分析結果皆低於八小時日時量平均容許濃度（Permit Exposure Level-Time Weighted Arerage, PEL-TWA）；ROS濃度以手工銲接與自動電銲區域之粒狀ROS濃度有較高之情形。勞工之肺部發炎反應指標TNF-α及MDA之分析結果顯示暴露組勞工有顯著偏高於對照組勞工；染色體端粒TL之分析結果則相反，此結果顯示勞工之職業暴露可能已經造成體內氧化傷害與發炎反應。重金屬分析結果顯示勞工之錳金屬與粒狀ROS暴露會導致勞工體內氧化傷害與染色體端粒變短，根據研究顯示染色體端粒長度變短與心血管疾病、高密度膽固醇累積與增加氧化傷害有關。

The working process in the production of fitness equipments includes welding, spray paint, assembly, test, packing and administration. The heavy metal, reactive oxygen species (ROS) might exist in their working departments. Therefore, the purpose of this study aims to assess the levels of metals and ROS activity generated from the manufacturing process and to assess the biological effects markers including malondialdehyde, DNA srand beaks, tail moment, telomere length (TL), tumor necrosis factor-α(TNF-α) and high sensitivity C-reactive protein (hs-CRP). The present study has shown that the highest ROS levels was found in welding area, and the following was in spray paint area. The metals analysis was below than PEL-TWA in all working areas; the highest ROS levels were found in manual welding areas and auto-welding areas. TNF-α and MDA levels were higher in exposure worker than in control workers, whereas for TL analysis. The result indicated that the inflammation and oxidative damage have elicited in this kind of workers. The present study showed that occupational Mn exposure and particulates ROS exposure would be in related to the oxidative damage and the short of TL. The TL shortening seemed to be as a new marker of cardiovascular disease, which might be in related to higher high-density lipoprotein cholesterol or at hypertensive subjects with increased leukocyte oxidative damage.

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