题名 |
疑似類固醇減量所引起的小兒假性腦瘤案例報告 |
并列篇名 |
A Suspected Case of Infant Pseudotumor Cerebri Induced by Tapering Corticosteroid |
作者 |
李純真(Chun-Chen Lee);黃仁治(Jen-Chih Huang);康智能(Chih-Neng Kang);李俐瑤(Li-Yao Lee);呂英豪(Ying-Hao Lu) |
关键词 |
假性腦瘤 ; 自發性腦內高血壓 ; mannitol ; acetazolamide ; 腰椎穿刺 ; pseudotumor cerebri ; idiopathic intracranial hypertension ; mannitol ; acetazolamide ; pediatric population |
期刊名称 |
臺灣臨床藥學雜誌 |
卷期/出版年月 |
20卷1期(2012 / 03 / 31) |
页次 |
35 - 48 |
内容语文 |
繁體中文 |
中文摘要 |
Introduction:Pseudotumor cerebri is also called idiopathic intracranial hypertension. It is characterized by high cerebrospinal fluid pressure with no underlying structural or systemic causes. Idiopathic intracranial hypertension of infant is described without papilledema because of unclosed fontanelles.Case Report:We reported a 7-month-old infant diagnosed with pancreatic hemangioma to be treated with high-dose corticosteroid (prednisolone 2 mg/kg/day). When pancreatic hemangioma was controlled, the dose of corticosteroid was rapidly tapered in last period. Due to irritability, vomiting, lethargy, and bulging fontanelles, this infant was taken to our emergency department. Intracranial pressure (ICP) was measured as 370 mmH2O (normal range of 0-2 years old infant: 75 mmH2O) without papilledema. Lumbar puncture was performed to drain cerebrospinal fluid for reducing intracranial pressure. Mannitol 10% and acetazolamide 125 mg/day were administered. Finally, the symptoms of idiopathic intracranial hypertension were well-resolved. In this, rapidly tapering high-dose corticosteroids may induce idiopathic intracranial hypertension.Conclusion:Idiopathic intracranial hypertension of infant could lead to the loss of vision. Dose reduction of corticosteroids after prolonged use should be always slow and clinicians should paid attention to the symptoms of idiopathic intracranial hypertension in pediatric population. |
英文摘要 |
Introduction:Pseudotumor cerebri is also called idiopathic intracranial hypertension. It is characterized by high cerebrospinal fluid pressure with no underlying structural or systemic causes. Idiopathic intracranial hypertension of infant is described without papilledema because of unclosed fontanelles.Case Report:We reported a 7-month-old infant diagnosed with pancreatic hemangioma to be treated with high-dose corticosteroid (prednisolone 2 mg/kg/day). When pancreatic hemangioma was controlled, the dose of corticosteroid was rapidly tapered in last period. Due to irritability, vomiting, lethargy, and bulging fontanelles, this infant was taken to our emergency department. Intracranial pressure (ICP) was measured as 370 mmH2O (normal range of 0-2 years old infant: 75 mmH2O) without papilledema. Lumbar puncture was performed to drain cerebrospinal fluid for reducing intracranial pressure. Mannitol 10% and acetazolamide 125 mg/day were administered. Finally, the symptoms of idiopathic intracranial hypertension were well-resolved. In this, rapidly tapering high-dose corticosteroids may induce idiopathic intracranial hypertension.Conclusion:Idiopathic intracranial hypertension of infant could lead to the loss of vision. Dose reduction of corticosteroids after prolonged use should be always slow and clinicians should paid attention to the symptoms of idiopathic intracranial hypertension in pediatric population. |
主题分类 |
醫藥衛生 >
藥理醫學 |