Linear Lupus Erythematosus Profundus: -Report of a Case and Review of the Literature-

線狀深部紅斑性狼瘡：－病例報告及文獻回顧－

10.29784/DS.200409.0003

邱政偉(Jeng-Wei Tjiu)；朱家瑜(Chia-Yu Chu)

Linear lupus erythematosus ； Linear lupus profundus

中華皮膚科醫學雜誌

22卷3期（2004 / 09 / 01）

221 - 226

英文

深部紅斑性狼瘡是一種少見的疾病，臨床表現特徵為紅色或是膚色的深層結節和板塊，特別好發在臀部、手臂、大腿和臉部。線狀變異型的深部紅斑性狼瘡在英文的文獻報告中只有四例。我們在此報告另一例線狀深部紅斑性狼瘡的案例。病人是一位26歲女性，從她的左手臂到左手掌有一條線形、硬結的紅色板塊。在病灶處的切片檢查顯示淋巴球性脂層炎併有透明脂肪壞死；直接免疫螢光檢查則發現顆粒樣IgM、C3和C1q在基底膜沉積。病人在使用口服hydroxy-chloroquine和局部類固醇與tacrolimus軟膏治療九個月後疾病活性獲得控制。

Lupus erythematosus profundus (LEP) a rare entity characterized by erythematous or flesh-colored deep nodules and plaques, with a predilection for the buttocks, arms, thighs and face. There are only 4 reported cases of linear variant of LEP in the English literature. We herein report another case of linear LEP. The patient was a 26-year-old female who presented with a linear indurated erythematous plaque along the left arm to her left palm. Skin biopsy taken from the lesion showed lymphocytic panni-culitis with hyaline fat necrosis. Direct immunofluorescence study revealed granular depositions of IgM, C3 and C1q along the basement membrane. She was treated with oral hydroxychloroquine, topical corticosteroids and topical tacrolimus ointment. Control of the disease activity was achieved after treatment for nine months.