停經前後體脂肪組成與血清瘦素值之研究

Body Fat Composition and Serum Leptin Levels before and after Menopause

10.6320/FJM.2000.4(1).02

黃國晉(Kuo-Chin Huang)；林瑞雄(Rue-Shen Lin)；陳慶餘(Ching-Yu Chen)；宋丕錕(Pei-Kun Sung)；周松男(Song-Nan Chow)

停經 ； 體脂肪 ； 瘦素 ； menopause ； body fat ； leptin

台灣醫學

4卷1期（2000 / 01 / 01）

8 - 13

繁體中文

People with android distribution of body fat are more susceptible to cardiovascular and metabolic diseases than those with a gynecoid distribution. The increased risk of cardiovascular diseases in postmenopausal women may be related to increased deposits and centralization of body fat. Leptin, the product of the ob gene, is a hormone secreted by fat cells. The role of fat mass regulation by leptin is well-established. This study investigated the relationship between serum leptin levels and menopausal status. Three hundred healthy women, aged 40 to 60, were recruited from a health clinic in Taipei from March to September 1998. We found that age, body mass index, waist circumference, waist-hip ratio and body fat deposits were higher in postmenopausal than in pre-menopausal women. Serum uric acid, total cholesterol, low-density lipoprotein cholesterol and triglycerides levels were also higher in postmenopausal than in premenopausal women. However, the body weight, hip circumference, glucose, high-density lipoprotein cholesterol and leptin levels were not statistically different in these women. Serum leptin levels were correlated with body fat weight (r=0.65), body fat proportion (r=0.62) and body mass index (r=0.61). Multiple linear regression analysis body fat weight independently predicted serum leptin levels, while age, menopausal status, body mass index and body fat proportion did not. Dyslipidaemia, greater deposit and centralization of body fat occur in postmenopausal women and are accompanied by an increased risk of cardiovascular diseases. Healthy life styles, dietary patterns and regular exercise are very important in women who enter into the postmenopausal period in order to control these increased risks.

People with android distribution of body fat are more susceptible to cardiovascular and metabolic diseases than those with a gynecoid distribution. The increased risk of cardiovascular diseases in postmenopausal women may be related to increased deposits and centralization of body fat. Leptin, the product of the ob gene, is a hormone secreted by fat cells. The role of fat mass regulation by leptin is well-established. This study investigated the relationship between serum leptin levels and menopausal status. Three hundred healthy women, aged 40 to 60, were recruited from a health clinic in Taipei from March to September 1998. We found that age, body mass index, waist circumference, waist-hip ratio and body fat deposits were higher in postmenopausal than in pre-menopausal women. Serum uric acid, total cholesterol, low-density lipoprotein cholesterol and triglycerides levels were also higher in postmenopausal than in premenopausal women. However, the body weight, hip circumference, glucose, high-density lipoprotein cholesterol and leptin levels were not statistically different in these women. Serum leptin levels were correlated with body fat weight (r=0.65), body fat proportion (r=0.62) and body mass index (r=0.61). Multiple linear regression analysis body fat weight independently predicted serum leptin levels, while age, menopausal status, body mass index and body fat proportion did not. Dyslipidaemia, greater deposit and centralization of body fat occur in postmenopausal women and are accompanied by an increased risk of cardiovascular diseases. Healthy life styles, dietary patterns and regular exercise are very important in women who enter into the postmenopausal period in order to control these increased risks.