Status Epilepticus Secondary to Venlafaxine Overdose

Venlafaxine過量導致癲癇重積狀態

10.29478/TJP.200612.0008

鄭怡君(Yi-Chun Cheng)；侯育銘(Yu-Ming Hou)；翁埈德(Cheung-Ter Ong)

venlafaxine過量／中毒 ； 癲癇 ； 自殺 ； venlafaxine overdose/intoxication ； seizure ； suicide

台灣精神醫學

20卷4期（2006 / 12 / 01）

316 - 320

英文

目的：報告一重鬱患者，在服用過量Venlafaxine後，出現癲癇重積狀態的病例，並討論其相關性。病例報告：18歲重鬱症女性，因自殺企圖，服用約7.5g venlafaxine後，出現癲癇重積狀態，經停用venlafaxine、給予抗癲癇藥物，並入加護病房接受支持性治療後，病情趨穩，於出院八個月後，沒有再出現癲癇發作。結論：venlafaxine過量可能會導致癲癇重積，但相關的機轉目前仍不清楚。因為癲癇重積是內科急症，可能造成許多併發症及後遺症，所以在高自殺危險群及有癲癇病史的病人，醫師需謹慎處方veulafaxine。

Objective: We report a case of status epilepticus (SE) secondary to venlafaxine overdose. Case report: An 18-year-old female with major depression developed SE after the ingestion of approximately 7.5g of venlafaxine in a suicide attempt. Supportive treatment was given including short-term use of anticonvulsants and anxiolytics (diazepam iv 15 mg, lorazepam iv 2 mg, and phenytoin iv drip 250 mg) within six hours after the first seizure. Her consciousness improved 12 hours later, and she recovered full consciousness within around 36 hours after the overdose. No recurrent seizure attacks or sequela occurred during the following 8-month period. Conclusion: Since venlafaxine overdose may induce SE, it should be prescribed with caution, especially to patients with suicidal tendencies or seizure history.

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