Weight Management Program for Overweight Patients with Schizophrenia: A 12-week Randomized Controlled Trial

體重控制計畫應用在體重過重之精神分裂症患者：十二週隨機對照臨床試驗

10.29478/TJP.200803.0008

黃斯聖(Si-Sheng Huang)；邱南英(Nan-Ying Chiu)

體重控制 ； 體重過重 ； 精神分裂症 ； 精神症狀 ； weight management ； overweight ； schizophrenia ； psychiatric symptom

台灣精神醫學

22卷1期（2008 / 03 / 01）

67 - 73

英文

Objective: To evaluate the effectiveness of a weight-management program for overweight schizophrenics. Methods: The patients were recruited from both the outpatient clinic and the psychiatric day hospital. They were randomly assigned to an intervention group (n=14) or control group (n=14). Values for body weight, body-mass index, and body fat were measured. We assessed psychiatric symptoms with the Clinical Global Impression-Severity and Brief Psychiatric Rating Scale. We used the two-tailed paired t-test to evaluate within-group changes. Between-group differences were assessed using univariate analysis of variance. Results: There was no significant change in body weight of the patients from baseline to endpoint for either group. The severity of psychiatric symptoms in the intervention group was decreased significantly (CGI-S:t=2.280, df=13, p=.040; BPRS: t=5.362, df=13, p＜.001). Conclusion: The body weight of the overweight schizophrenics did not decrease by this program, however, their psychiatric symptoms were improved by it. The results need to be duplicaled in future studies.

Objective: To evaluate the effectiveness of a weight-management program for overweight schizophrenics. Methods: The patients were recruited from both the outpatient clinic and the psychiatric day hospital. They were randomly assigned to an intervention group (n=14) or control group (n=14). Values for body weight, body-mass index, and body fat were measured. We assessed psychiatric symptoms with the Clinical Global Impression-Severity and Brief Psychiatric Rating Scale. We used the two-tailed paired t-test to evaluate within-group changes. Between-group differences were assessed using univariate analysis of variance. Results: There was no significant change in body weight of the patients from baseline to endpoint for either group. The severity of psychiatric symptoms in the intervention group was decreased significantly (CGI-S:t=2.280, df=13, p=.040; BPRS: t=5.362, df=13, p＜.001). Conclusion: The body weight of the overweight schizophrenics did not decrease by this program, however, their psychiatric symptoms were improved by it. The results need to be duplicaled in future studies.

1. Ball MP,Coons VB,Buchanan RW(2001).A program for treating olanzapine-related weight gain.Psychiatr Serv,52,967-969.
2. Coodin S(2001).Body mass index in persons with schizophrenia.Can J Psychiatry,46,549-555.
3. Guthrie SK(2002).Clinical issues associated with maintenance treatment of patients with schizophrenia.Am J Health Syst Pharm,59(17 Suppl 5),19-24.
4. Kwon JS,Choi JS,Bahk WM(2006).Weight management program for treatment-emergent weight gain in olanzapine-treated patients with schizophrenia or schizoaffective disorder: A 12- week randomized controlled clinical trial.J Clin Psychiatry,67,547-553.
5. Littrell KH,Hilligoss NM,Kirshner CD,Petty RG,Johnson CG(2003).The effects of an educational intervention on antipsychotic-induced weight gain.J Nur Scholarship,35,237-241.
6. Strassnig M,Brar JS,Ganguli R(2003).Body mass index and quality of life in community-dwelling patients with schizophrenia.Schizophr Res,63,73-76.
7. Vreeland B,Minsky S,Menza M,Rigassio Radler D,Roemheld-Hamm B,Stern R(2003).A program for managing weight gain associated with atypical antipsychotics.Psychiatr Serv,54,1155-1157.
8. Weber M,Wyne K(2006).A cognitive/behavioral group intervention for weight loss in patients treated with atypical antipsychotics.Schizophr Res,83,95-101.
9. Wu MK,Wang CK,Bai YM,Huang CY,Lee SD(2007).Outcomes of obese, clozapine-treated inpatients with schizophrenia placed on a six-month diet and physical activity program.Psychiatr Serv,58,544-550.

1. 蔡芸芳、吳玉茹、吳文正、王鐘賢(2016)。體感式電玩介入對慢性思覺失調症病人健康體適能之成效。護理雜誌，63(1)，49-58。