Cytokines and Major Psychiatric Disorders

細胞激素與精神疾患

10.29478/TJP.201012.0002

張婷婷(Ting-Ting Chang)；顏永杰(Yung-Chieh Yen)

Cytokine ； schizophrenia ； major depressive disorder ； bipolar disorder

台灣精神醫學

24卷4期（2010 / 12 / 01）

257 - 268

英文

Background: Severe mental disorders are chronic, recurrent and usually combined chronic physical illness. The pathophysiology of mental disorder still remains a mystery. Convincing evidence supports that cytokines play an integral role in the pathophysiology of certain psychiatric disorders including schizophrenia, major depressive disorder, and bipolar disorder. Method: In this comprehensive overview, we reviewed all available published articles on the topic of cytokines and major psychiatric disorders. Results: Cytokine are generally known as chemical messengers between immune cells. As such, they play a crucial role in mediating inflammatory and immune responses. Cytokines can signal the brain and serve as a mediators between immune and nerve cells. The brain is now seen as capable of influencing immune processes. Conversely, changes in brain activity can occur in association with an immunologic response. Cytokines can act as neuromodulators within the brain. Therefore, cytokines can affect important brain activities such as sleep, appetite, and neuroedocrine regulation. Conclusion: Discoveries about these processes have led to speculations about a possible link between cytokines and psychopathology. If we could identify the immunologic defects in psychiatric disorders, novel treatment strategies involving cytokines and/or cytokine inhibitors would be designed and tried clinically in the future.

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