题名

Dramatic Improvement of Obsessive-compulsive Symptoms after a Single Electroconvulsive Therapy

并列篇名

強迫症在單次電氣痙攣治療後症狀急速改善

DOI

10.29478/TJP.201012.0009

作者

李柏賢(Bo-Shyan Lee);許文郁(Wen-Yu Hsu);邱南英(Nan-Ying Chiu);黃斯聖(Si-Sheng Huang)

关键词

ECT ; OCD ; YBOCS ; MDD

期刊名称

台灣精神醫學

卷期/出版年月

24卷4期(2010 / 12 / 01)

页次

318 - 321

内容语文

英文

英文摘要

Background: Electroconvulsive therapy (ECT) is usually the last-line treatment in clinical psychiatric practice. But, many patients with major psychiatric disorders who are severely ill, resisting, or intolerant to medication, may respond more reliably and quickly to ECT. Case Report: We report a 37-year-old male patient with obsessive compulsive disorder (OCD) and major depressive disorder (MDD). He had a dramatic change of Yale Brown Obsessive-compulsive Scale score after his receiving a single treatment with ECT. Conclusion: ECT with medication showed dramatic therapeutic effect in obsessive-compulsive symptoms in a patient with MDD and OCD. But clinical observations with a larger number of cases are needed to verify our successful experience with ECT in this patient.

主题分类 醫藥衛生 > 社會醫學
参考文献
  1. Altar, C.A.,Laeng, P.,Jurata, L.W.(2004).Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways.J Neurosci,24,2667-2677.
  2. Critchley, H.D.,Mathia, C.J.,Dolan, R.J.(2001).Neural activity in the human brain relating to uncertainty and arousal during anticipation.Neuron,29,537-545.
  3. Denys, D.,van der Wee, N.,van Megen, H.J.(2003).A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder.J Clin Psychopharmacol,23,568-575.
  4. Kontis, D.,Boulougouris, V.,Papakosta, V.M.(2008).Dopaminergic and serotonergic modulation of persistent behaviour in the reinforced spatial alternation model of obsessive-compulsive disorder.Psychopharmacology,200,597-610.
  5. Rolls, E.T.(2000).The orbitofrontal cortex and reward.Cereb Cortex,10,284-294.
  6. Schnider, A.,Treyer, V.,Buck, A.(2005).The human orbitofrontal cortex monitors outcomes even when no reward is at stake.Neuropsychologia,43,316-323.
  7. Selvin, B.L.(1987).Electroconvulsive therapy.Anesthesiology,67,367-385.
  8. Sermet, E.,Gregoire, M.C.,Galy, G.(1998).Paradoxical metabolic response of the human brain to a single electroconvulsive shock.Neurosci Lett,254,41-44.
  9. Thomas, S.G.,Kellner, C.H.(2003).Remission of major depression and obsessive-compulsive disorder after a single unilateral ECT.J ECT,19,50-51.
  10. Westenberg, H.G.,Fineberg, N.A.,Denys, D.(2007).Neurobiology of obsessive-compulsive disorder: serotonin and beyond.CNS Spectr,12(2 Suppl 3),14-27.