题名

A Patient with Tuberous Sclerosis Complex with Manic Features

并列篇名

多發性結節性硬化症合併躁症表現

DOI

10.29478/TJP.201106.0007

作者

黃繼賢(Chi-Hsien Huang)；顏永杰(Yung-Chieh Yen)

关键词

tuberous sclerosis complex ； mania ； adolescent

期刊名称

台灣精神醫學

卷期/出版年月

25卷2期（2011 / 06 / 01）

页次

106 - 109

内容语文

英文
英文摘要

Background: Tuberous sclerosis complex is a genetic disorder affecting multiple organs including the heart, lungs, brain, skin, and kidneys. But manic features are seldom documented in a previous literature review. Case Report: The female adolescent patient had tuberous sclerosis complex manifesting with manic symptoms. Her initial presentation included akathisia, poor concentration and queer behavior such as spinning around during her preschool years. She did not get a satisfactory treatment effect with medication under an original suspicion of absence seizure. Based on cutaneous findings such as hypomelanotic macules, a shagreen patch and facial angiofibromas, the diagnosis of tuberous sclerosis complex was confirmed at age 10 years. Her first manic episode appeared when she was 18 years old. Conclusion: Clinicians should be alert to have the possibility of tuberous sclerosis complex with the presentation of any specific cutaneous findings along with seizure attacks. Secondary mania may be associated with tuberous sclerosis complex although further genetic research are needed to clarify the etiological relationship.
主题分类 醫藥衛生 > 社會醫學
参考文献
  1. Bear, DM,Fedio, P(1977).Quantitative analysis of interictal behavior in temporal lobe epilepsy.Arch Neurol,34,454-67.
  2. Chopra, VK,Cintury, Y,Sinha, VK(2006).Bipolar disorder associated with tuberous sclerosis: chance association or aetiological relationship?.Indian J Psychiatry,48,66-8.
  3. Cummings, JL(1986).Organic psychoses. delusional disorders and secondary mania.Psychiatr Clin North Am,9,293-311.
  4. Daniels, RJ,Peden, JF,Lloyd, C(2001).Sequence,structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.Hum Mol Genetics,10,339-52.
  5. Gregory, LH,Carl, ES(2007).The Tuberous Sclerosis Study Group: Critical review: tuberous sclerosis complex and epilepsy: recent developments and future challenges.Epilepsia,48,617-30.
  6. Hagenah, U,Coners, H,Kotlarek, F,Herpertz-Dahlmann, B(1999).Tuberous sclerosis and organic bipolar disorder in a 15-year-old adolescent.Kinder Jugendpsychiatr Psychother,27,283-9.
  7. Haq, MZ,Dubey, I,Khess, CR,Das, U,Kumar, R(2009).Bipolar disorder and tuberous sclerosis complex: is it a mere coincidence?.CNS Spectr,14,643-7.
  8. Khanna, R,Borde, M(1989).Mania in a five-year-old child with tuberous sclerosis.Brit J Psychiatry,155,117-9.
  9. Small, JG,Milstein, V,Malloy, FW,Medlock, CE,Klapper, MH(1999).Clinical and quantitative EEG studies of mania.J Affect Disord,53,217-24.
  10. Small, JG,Milstein, V,Medlock, CE(1997).Clinical EEG findings in mania.Clin Electroencephalogr,28,229-35.
print cancel