题名

Decreased White Blood Cell Count Related to Haloperidol Add-on Treatment to Olanzapine

并列篇名

併用Haloperidol於Olanzapine後出現白血球降低

DOI

10.29478/TJP.201106.0009

作者

黃偉烈(Wei-Lieh Huang)；林朝誠(Chao-Cheng Lin)；廖士程(Shih-Cheng Liao)

关键词

leukopenia ； neutropenia ； haloperidol ； olanzapine

期刊名称

台灣精神醫學

卷期/出版年月

25卷2期（2011 / 06 / 01）

页次

115 - 118

内容语文

英文
英文摘要

Background: Leukopenia is a potentially severe side effect of antipsychotic drugs. Clozapine, olanzapine, and chlorpromazine are found to induce leukopenia. Haloperidol-induced leukopenia is occasionally reported. Research are limited to explore hematologic side effects related to the combined use of olanzapine and haloperidol. Case Report: We present a case of a patient with schizophrenia, whose white blood cell count was decreased following receiving a combination of haloperidol and olanzapine, and increased rapidly after discontinuing haloperidol. Conclusion: This case reminds us paying attention to the leukopenic effect of the use of haloperidol or combined antipsychotic drugs. Encountering a patient with a suspected antipsychotics-induced hematologic problem, clinicians need to consider those frequently mentioned offending agents, and to observe its relation with other antipsychotic drugs.
主题分类 醫藥衛生 > 社會醫學
参考文献
  1. Abdullah, N,Voronovitch, L,Taylor, S(2003).Olanzapine and haloperidol: potential for neutropenia?.Psychosomatics,44,83-4.
  2. Copolov, D,Bell, W,Benson, W(1998).Clozapine treatment in Australia: a review of haematological monitoring.Med J Aust,168,495-7.
  3. Delieu, J,Horobin, R,Duguid, J(2006).Formation of immature neutrophil leucocytes in schizophrenic patients treated with various antipsychotic drugs: comparisons and predictions.J Psychopharmacol,20,824-8.
  4. Flanagan, RJ,Dunk, L(2008).Haematological toxicity of drugs used in psychiatry.Hum Psychopharmacol,23,27-41.
  5. Gajwani, P,Tesar, G(2000).Olanzapine-induced neutropenia.Psychosomatics,41,150-1.
  6. Gardos, G(2005).Antipsychotic polypharmacy or monotherapy?.Neuropsychopharmacol Hung,7,72-7.
  7. Ghaznavi, S,Nakic, M,Rao, P(2008).Rechallenging with clozapine following neutropenia: treatment options for refractory schizophrenia.Am J Psychiatry,165,813-8.
  8. Hall, R,Smith, A,Edwards, JG(2003).Haematological safety of antipsychotic drugs.Expert Opin Drug Saf,2,395-9.
  9. Kodesh, A,Finkel, B,Lerner, A(2001).Dose-dependent olanzapine-associated leukopenia: three case reports.Int Clin Psychopharmacol,16,117-9.
  10. Naranjo, CA,Busto, U,Sellers, EM(1982).Difficulties in assessing adverse drug reactions in clinical trials.Prog Neuropsychopharmacol Biol Psychiatry,6,651-7.
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