题名

Leukopenia Induced by Quetiapine in a Patient with History of Clozapine-induced Leukopenia

并列篇名

Quetiapine引發白血球減少症於曾有Clozapine 引起之白血球減少症病史之病患

DOI

10.29478/TJP.201109.0008

作者

王智仁(Chih-Jen Wang)；張正辰(Cheng-Chen Chang)；黃斯聖(Si-Sheng Huang)

关键词

clozapine ； quetiapine ； leukopenia ； blood dyscrasia

期刊名称

台灣精神醫學

卷期/出版年月

25卷3期（2011 / 09 / 01）

页次

191 - 194

内容语文

英文
英文摘要

Objective: Many antipsychotic medications can cause hematological abnormalities. Quetiapine is a dibenzothiazepine derivative similar to clozapine, an antipsychotic agent which has the highest risk of causing blood dyscrasias. A case of quetiapine-induced leukopenia is described here in a patient who had a previous history of leukopenia induced by clozapine. Case Report: A 34-year-old Taiwanese woman patient with schizophrenia had a history of clozapine-induced leukopenia. She developed leukopenia again after her receiving quetiapine treatment. After quetiapine was discontinued, her white blood count was increased to a normal range. Conclusion: Physicians should be cautious of having potential hematological abnormalities before prescribing leukopenia-causing drugs, especially in patients with a history of drug-induced leukopenia.
主题分类 醫藥衛生 > 社會醫學
参考文献
  1. Clark, N,Weissberg, E,Noel, J(2001).Quetiapine and leukopenia.Am J Psychiatry,158,817-818.
  2. Cowan, C,Oakley, C(2007).Leukopenia and neutropenia induced by quetiapine.Prog Neuro-psychopharmacol Biol Psychiatry,31,292-294.
  3. Dunk, LR,Annan, LJ,Andrews, CD(2006).Rechallenge with clozapine following leucopenia or neutropenia during previous therapy.Br J Psychiatry,188,255-263.
  4. Guzelcan, Y,Scholte, WF(2006).Clozapine-induced agranulocytosis: genetic risk factors and an immunologic explanatory model.Tijdschrift voor Psychiatrie,48,295-302.
  5. Nair, P,Lippmann, S(2005).Is leukopenia associated with divalproex and/or quetiapine?.Psychosomatics,46,188-189.
  6. Pereira, A,Dean, B(2006).Clozapine bioactivation induces dose-dependent, drug-specifi c toxicity of human bone marrow stromal cells: a potential in vitro system for the study of agranulocytosis.Biochem Pharmacol,72,783-793.
  7. Pessina, A,Turlizzi, E,Bonomi, A(2006).In vitro toxicity of clozapine, olanzapine, and quetiapine on granulocyte-macrophage progenitors (GM-CFU).Pharmacopsychiatry,39,20-22.
  8. Shankar, BR(2007).Quetiapine-induced leucopenia and thrombocytopenia.Psychosomatics,48,530-531.
  9. Theodoropoulou, S,Pappa, H,Lykouras, L,Papageorgiou, G,Papasteriades, C,Sakalis, G(1997).Human leukocyte antigen system in clozapine-induced agranulocytosis.Neuropsychobiology,36,5-7.
  10. Turbay, D,Lieberman, J,Alper, CA(1997).Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups.Blood,89,4167-4174.
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