题名

Cytokines, Treatment Responses, and Body Weight Changes in Major Depressive Patients Treated with Antidepressants

并列篇名

抗鬱劑治療前後重鬱症病人之細胞因子、治療反應、以及體重變化之關係

作者

林敬淳(Chin-Chuen Lin)；李建德(Chien-Te Lee)；黃條來(Tiao-Lai Huang)

关键词

抗憂鬱劑 ； 體重 ； 細胞因子 ； 重鬱症 ； antidepressant ； body weight ； cytokine ； major depression

期刊名称

台灣精神醫學

卷期/出版年月

28卷2期（2014 / 06 / 01）

页次

ii+95 - 102

内容语文

英文
中文摘要

目的：血清中的細胞因子濃度可能與重鬱症急性期之致病機轉有關。此研究探討細胞因子濃度、治療反應、以及體重變化在重鬱症病人接受四週抗鬱劑治療後的關係。方法：五十四位重鬱症病人血清中的干擾素γ（interferon-γ, IFN-γ）、腫瘤壞死因子α（tumor necrosis factor-α, TNF-α）、白細胞介素10（interleukin-10, IL-10）、以及轉化生長因子β1（transforming growth factorβ1, TGF-β1）以酵素免疫分析法測量。精神科診斷依據DSM-IV。重鬱症之嚴重度則以十七題漢式憂鬱量表評估。結果：接受治療前，之後對抗鬱劑反應佳的病人有顯著較低的IL-10濃度（p = 0.001）及顯著較低的IL-10/TGF-β1比例（p ＜ 0.01）。接受抗鬱劑治療後，在所有的病人中，體重變化與TNF-α/TGF-β1比例變化有顯著的正相關（p ＜ 0.05）。若只分析對抗鬱劑反應佳的病人，體重變化與TNF-α/TGF-β1比例變化仍有有顯著的正相關（p ＜ 0.05）。但若只分析對抗鬱劑反應不佳的病人，體重變化則與IL-10/TGF-β1比例變化有顯著的負相關（p ＜ 0.01）。結論：血清中的TNF-α、IL-10、以及TGF-β1可能可以用來預測重鬱症病人對抗鬱劑治療之反應及治療後體重的變化。
英文摘要

Objectives: Serum cytokine levels are implicated in the action of mechanism for acute-phase major depression. In this study, we intended to investigate the relationships between cytokine serum levels and treatment responses as well as body weight changes after a four-week antidepressant treatment in patients with major depressive disorders. Methods: Fifty-four major depressive patients were recruited. Their serum cytokine levels of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), and transforming growth factor β1 (TGF-β1) were examined using ELISA kits. Psychiatric diagnoses were made using the DSM-IV criteria. Severity of major depression was assessed using the 17-item Hamilton Depression Rating Scale. Results: We found significantly lower baseline serum IL-10 level (p = 0.001) and significantly lower baseline IL-10/TGF-β1 ratio (p ＜ 0.01) in responders compared to those in non-responders. In all patients after antidepressant treatment, we found a significant positive correlation between body weight change and TNF-α/TGF-β1 ratio change (p ＜ 0.05). In responders alone, a significant positive correlation between body weight change and TNF-α/ TGF-β1 ratio change (p ＜ 0.05) was found. In non-responders, a significant negative correlation between body weight change and IL-10/TGF-β1 ratio change (p ＜ 0.01) was found. Conclusion: Serum levels of TNF-α, IL-10 and TGF-β1 could be used to predict the treatment response and body weight change in patients with major depression.
主题分类 醫藥衛生 > 社會醫學
参考文献
  1. Chang, TT,Yen, YC(2010).Cytokines and Major Psychiatric Disorders.Taiwanese Journal of Psychiatry,24,257-68.
    連結：
  2. Baune, BT,Dannlowski, U,Domschke, K(2010).The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression.Biol Psychiatry,67,543-9.
  3. Bornstein, SR,Schuppenies, A,Wong, ML,Licinio, J(2006).Approaching the shared biology of obesity and depression: the stress axis as the locus of gene-environment interactions.Mol Psychiatry,11,892-902.
  4. Cartier, A,Lemieux, I,Almeras, N,Tremblay, A,Bergeron, J,Despres, JP(2008).Visceral obesity and plasma glucose-insulin homeostasis: contributions of interleukin-6 and tumor necrosis factor-alpha in men.J Clin Endocrinol Metab,93,1931-8.
  5. Dowlati, Y,Herrmann, N,Swardfager, W(2010).A meta-analysis of cytokines in major depression.Biol Psychiatry,67,446-57.
  6. Eller, T,Vasar, V,Shlik, J,Maron, E(2008).Pro-infl ammatory cytokines and treatment response to escitalopram in major depressive disorder.Prog Neuropsychopharmacol Biol Psychiatry,32,445-50.
  7. Fontana, L,Eagon, JC,Trujillo, ME,Scherer, PE,Klein, S(2007).Visceral fat adipokine secretion is associated with systemic infl ammation in obese humans.Diabetes,56,1010-3.
  8. Hamilton, M(1960).A rating scale for depression.J Neurol Neurosurg Psychiatry,23,56-62.
  9. Hantsoo, L,Ward-O'Brien, D,Czarkowski, KA,Gueorguieva, R,Price, LH,Epperson, CN(2013).A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression.Psychopharmacology
  10. Islam, A,Chen, Y,Poth, M,Smith, ZP,Deuster, PA(2012).Glucocorticoid receptor density correlates with health risk factors and insulin resistance in Caucasian and African American subjects.Exp Clin Endocrinol Diabetes,120,477-81.
  11. Kern, PA,Ranganathan, S,Li, C,Wood, L,Ranganathan, G(2001).Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance.Am J Physiol Endocrinol Metab,280,E745-51.
  12. Kern, PA,Saghizadeh, M,Ong, JM,Bosch, RJ,Deem, R,Simsolo, RB(1995).The expression of tumor necrosis factor in human adipose tissue: regulation by obesity, weight loss, and relationship to lipoprotein lipase.J Clin Invest,95,2111-9.
  13. Khan, A,Schwartz, KA,Kolts, RL,Brown, WA(2007).BMI, sex, and antidepressant response.J Affect Disord,99,101-6.
  14. Krishnadas, R,Cavanagh, J(2012).Depression: an inflammatory ammatory illness?.J Neurol Neurosurg Psychiatry,83,495-502.
  15. Kubera, M,Lin, AH,Kenis, G,Bosmans, E,van Bockstaele, D,Maes, M(2001).Anti-Infl ammatory effects of antidepressants through suppression of the interferon-gamma/interleukin-10 production ratio.J Clin Psychopharmacol,21,199-206.
  16. Lanquillon, S,Krieg, JC,Bening-Abu-Shach, U,Vedder, H(2000).Cytokine production and treatment response in major depressive disorder.Neuropsychopharmacology,22,370-9.
  17. Leonard, BE(2010).The concept of depression as a dysfunction of the immune system.Current Immunol Rev,6,205-12.
  18. Leonard, BE(2005).The HPA and immune axes in stress: the involvement of the serotonergic system.Eur Psychiatry,20(Suppl 3),S302-6.
  19. Liew, FY(2002).T(H)1 and T(H)2 cells: a historical perspective.Nature Rev Immunol,2,55-60.
  20. Maes, M,Bosmans, E,Suy, E,Vandervorst, C,DeJonckheere, C,Raus, J(1991).Depression-related disturbances in mitogen-induced lymphocyte responses and interleukin-1 beta and soluble interleukin-2 receptor production.Acta Psychiatr Scand,84,379-86.
  21. Maes, M,Delange, J,Ranjan, R(1997).Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs.Psychiatry Res,66,1-11.
  22. Martino, M,Rocchi, G,Escelsior, A,Fornaro, M(2012).Immunomodulation mechanism of antidepressants: interactions between serotonin/norepinephrine balance and Th1/Th2 balance.Current Neuropharmaco,10,97-123.
  23. Miller, AH,Pariante, CM,Pearce, BD(1999).Effects of cytokines on glucocorticoid receptor expression and function. Glucocorticoid resistance and relevance to depression.Adv Exp Med Biol,461,107-16.
  24. Mosmann, TR,Coffman, RL(1989).TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties.Annu Rev Immunol,7,145-73.
  25. Myint, AM,Leonard, BE,Steinbusch, HW,Kim, YK(2005).Th1, Th2, and Th3 cytokine alterations in major depression.J Affect Disord,88,167-73.
  26. Myint, A-M,Leonard, BE,Steinbusch, HWM,Kim, Y-K(2005).Th1, Th2, and Th3 cytokine alterations in major depression.J Affect Disord,88,167-73.
  27. O'Brien, SM,Scully, P,Fitzgerald, P,Scott, LV,Dinan, TG(2007).Plasma cytokine profi les in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy.J Psychiatr Res,41,326-31.
  28. O'Garra, A(1998).Cytokines induce the development of functionally heterogeneous T helper cell subsets.Immunity,8,275-83.
  29. Pace, TW,Hu, F,Miller, AH(2007).Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression.Brain Behav Immun,21,9-19.
  30. Path, G,Bornstein, SR,Gurniak, M,Chrousos, GP,Scherbaum, WA,Hauner, H(2001).Human breast adipocytes express interleukin-6 (IL-6) and its receptor system: increased IL-6 production by beta-adrenergic activation and effects of IL-6 on adipocyte function.J Clin Endocrinol Metab,86,2281-8.
  31. Pavon, L,Sandoval-Lopez, G,Eugenia Hernandez, M(2006).Th2 cytokine response in Major Depressive Disorder patients before treatment.J Neuroimmunol,172,156-65.
  32. Raison, CL,Capuron, L,Miller, AH(2006).Cytokines sing the blues: infl ammation and the pathogenesis of depression.Trends Immunol,27,24-31.
  33. Schiepers, OJG,Wichers, MC,Maes, M(2005).Cytokines and major depression.Prog Neuropsychopharmacol Biol Psychiatry,29,201-17.
  34. Schmitt, E,Hoehn, P,Huels, C(1994).T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin-12 and interferon-gamma and is inhibited by transforming growth factorbeta.Eur J Immunol,24,793-8.
  35. Seidel, A,Arolt, V,Hunstiger, M,Rink, L,Behnisch, A,Kirchner, H(1995).Cytokine production and serum proteins in depression.Scand J Immunol,41,534-8.
  36. Song, C,Dinan, T,Leonard, BE(1994).Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls.J Affect Disord,30,283-8.
  37. Sutcigil, L,Oktenli, C,Musabak, U(2007).Pro- and anti-infl ammatory cytokine balance in major depression: effect of sertraline therapy.Clin Dev Immunol,2007,76396.
  38. Swain, SL,Huston, G,Tonkonogy, S,Weinberg, A(1991).Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.J Immunol,147,2991-3000.
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