Sex Differences Influence Correlates of P300 in Drug-naïve Patients with Schizophrenia

未服藥思覺失調症病人的P300相關因子之性別差異

張維紘(Wei Hung Chang)；陳高欽(Kao Chin Chen)；楊延光(Yen Kuang Yang)；陳柏熹(Po See Chen)；陸汝斌(Ru-Band Lu)；葉宗烈(Tzung Lieh Yeh)；李怡慧(I Hui Lee)

drug-naïve schizophrenia ； P300 ； psychopathologies ； sex differences ； 認知功能 ； 未服藥思覺失調症 ； P300 ； 精神病理學 ； 性別差異

台灣精神醫學

31卷3期（2017 / 09 / 01）

204 - 213+iii

英文

Objectives: The objective of this study was to explore how sex differences influence the correlations between P300 and cognitive function as well as the severity of psychopathologies in drug-naïve patients with schizophrenia. Methods: The study included 28 drug-naïve patients with schizophrenia (male = 15, female = 13, mean age = 24.03 ± 5.67 years). Clinical psychopathology and cognitive function were measured using Positive and Negative Syndrome Scale (PANSS) and the Wechsler Memory Scale-Revised (WMS-R), respectively. We also assessed Spearman’s r correlations and partial correlations, controlling participants’ age and the duration of illness, between P300 and cognitive functions/psychopathologies. Results: In the male patients with schizophrenia, the significant correlations existed between the latency of P300 at the midline electrodes (central electrode (Cz) and parietal electrode (Pz)) and the scores of negative symptoms in PANSS (p ＜ 0.05, p ＜ 0.001). Also, the significant positive correlation existed between positive symptoms in PANSS and latency of P300 at Pz only in male subjects (p ＜ 0.05). In the female patients, the latency of P300 at Cz was significantly correlated with both the verbal memory and attention/concentration index of the WMS-R (p ＜ 0.01) respectively, and the amplitude of P300 at Pz was significantly correlated with visual memory index (ρ = 0.61, p ＜ 0.05). The above significances still existed after controlling patients’ age and the duration of illness (p ＜ 0.05). But after multiple comparison, only significant correlation existed between the latency of P300 at Pz and the scores of negative symptoms in PANSS in male subjects (ρ = 0.88, p ＜ 0.001). Conclusion: Our study revealed that the correlations between clinical symptoms and P300 variations may be sex-linked.

目的：本研究目的為探討性別如何影響未服藥思覺失調症病人的P300 和認知功能以及精神症狀嚴重度。方法：本研究招募28 位（男15 位，女13 位，平均年齡24.03 ± 5.67）未服藥的思覺失調症病人。臨床精神症狀嚴重度與認知功能分別由PANSS（活性與負性症狀量表）和WMS-R（魏氏記憶量表第二版）測量，並以斯皮爾曼相關統計（控制年齡和病齡的偏相關）來測量P300 與認知功能及精神症狀之關聯程度。結果：男性病人中，中央極(Cz) 與頂葉極 (Pz) 的潛時P300 與負性症狀有顯著正相關 (p ＜ 0.05) 。女性病人中，Cz 潛時P300 和魏氏記憶量表第二版的語言記憶與注意力／集中力指標有顯著正相關 (p ＜ 0.01)。以上相關在控制年齡和病齡後仍然顯著 (p ＜ 0.05)。但經過多重較正後，僅男性病人之Pz 潛時與負性症狀相關仍然顯著相關 (p ＜ 0.001)。結論：本研究顯示未服藥思覺失調症病人的臨床症狀與P300 的相關是有性別差異的。

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