重複經顱磁刺激技術對阿茲海默症治療的研究進展

Advances in Repetitive Transcranial Magnetic Stimulation for the Treatment of Alzheimer's Disease

殷婷婷(Ting-Ting Yin)；黃芊芊(Qian-Qian Huang)；蘇裕盛(Yu-Sheng Su)

阿茲海默症 ； 非侵入性腦刺激技術 ； 重複經顱刺激技術 ； Alzheimer's disease ； Non-invasive brain stimulation techniques ； Repetitive transcranial stimulation techniques

元培學報

26期（2023 / 06 / 01）

73 - 85

繁體中文;英文

阿茲海默症（Alzheimer's disease，AD）是一種退行性神經疾病，目前尚無治療AD的特效藥物，故藥物干預僅提供了次優的益處。AD的治療方法除藥物治療外，多採用非藥物治療方法包括經顱磁刺激（Transcranial magnetic stimulation，TMS）技術，重複經顱磁刺激（Repetitive transcranial magnetic stimulation，rTMS）是TMS的一種重複運用形式。TMS原理是基於法拉第電磁感應定律，電磁場（Electromagnetic field，EMF）的方式來刺激大腦，這對於作為一種有關大腦的神經退行性疾病AD而言十分重要，rTMS作為一種無創且有效的、可以改善AD患者的認知功能、記憶和語言能力的治療方法，這些功能的下降都是AD的患病特徵。近年來rTMS成為了各種神經退行性疾病的有效治療工具而逐漸得到重視，迅速成為治療輕度認知障礙（Mild cognitive impairment，MCI）和輕、中度AD的有效方法，有望代替藥物治療的方法對AD患者進行治療。故此探究針對於rTMS對AD的有作用效果的部位，包括皮質、海馬體及突觸等，並通過rTMS的各種參數包括刺激強度、刺激頻率、持續作用時間等總結rTMS對AD刺激、治療效果的影響。在此探討rTMS對AD的作用部位和rTMS各參數對AD症狀進程的影響，結果發現高頻率、較高強度、長持續時間對AD治療的效果好。

Alzheimer's disease (AD) is a degenerative neurological disease, and there are currently no specific drugs for treating AD, so drug intervention only provides suboptimal benefits. The treatment methods for AD, in addition to drug therapy, often use non drug treatment methods including transcranial magnetic stimulation (TMS) technology. Repetitive transcranial magnetic stimulation (rTMS) is a form of repeated use of TMS. The principle of TMS is based on Faraday's law of electromagnetic induction, which stimulates the brain through electromagnetic fields (EMFs). This is crucial for AD, a neurodegenerative disease related to the brain. As a non-invasive and effective treatment method that can improve cognitive function, memory, and language abilities in AD patients, rTMS is characterized by the decline of these functions. In recent years, rTMS has become an effective treatment tool for various neurodegenerative diseases and has gradually gained attention. It has quickly become an effective method for treating mild cognitive impairment (MCI) and mild to moderate AD, and is expected to replace drug therapy for the treatment of AD patients. Therefore, this research is aimed at exploring the parts of rTMS that have effects on AD, including cortex, hippocampus, and synapse. The effects of rTMS on AD stimulation and treatment effects are summarized through various parameters of rTMS, including stimulation intensity, stimulation frequency, and duration of action. Therefore, this research is to explore the effects of rTMS on AD and the effects of rTMS parameters on AD symptom process. The results show that high frequency, high intensity, and long duration have good effects on AD treatment.