Antibacterial activity of gypsum-based biomaterial compared to calcium hydroxide and glass ionomer cement on streptococcus sobrinus: an in vitro study

Hasan Subhi；Nicholas Thong Li Jie；Ikhwan Hakimi；Fazal Reza；Adam Husein；Asma Abdullah Nuru

Direct pulp capping ； Gypsum ； Chitosan ； Streptococcus sobrinus

Journal of International Dental and Medical Research

11卷2期（2018 / 07 / 01）

477 - 481

英文

Direct pulp capping (DPC) is initiated to preserve the healthy state of the pulp tissue that has been compromised by trauma, restorative procedures, or caries. It involves the application of a suitable dental material to seal communications between the oral cavity and the exposed pulp. DPC is challenging due to bacterial infection. This study aimed to investigate the antibacterial activity of gypsum-based biomaterial (Gyp- CHT) compared to Dycal (DYC) and Glass ionomer cement (GIC) on Streptococcus sobrinus. S. sobrinus were seeded on the surface of brain-heart infusion (BHI) agar. Gyp-CHT with various concentrations of chitosan (CHT), DYC, and GIC were then inserted in the wells of the agar. The diameter of the inhibition zones produced around the materials were measured after 48 hrs. Gyp-10%CHT has the highest antibacterial activity compared to DYC and GIC (p＜0.05). In addition, significantly decreased antibacterial activity (p＜0.05) was observed with Gypsum (Gyp) alone compared with 2.5%CHT, 5%CHT, and 10%CHT- containing Gyp. Gyp-CHT has potent antibacterial activity against S. sobrinus. Gyp-CHT is a promising candidate for use as a pulp capping material.