Degradation of Resin-Dentin Bonded Interface: A Review

Jadesada Palasuk

MMPs ； hydrolysis ； degradation ； hybrid layer

Journal of International Dental and Medical Research

11卷2期（2018 / 07 / 01）

537 - 542

英文

Hybrid layer can be described as the resin impregnated demineralized dentin layer. It comprises of the adhesive resin and the collagen fibrils that serve as scaffold for resin infiltration. Degradation of the hybrid layer is one of the major investigated topics in the restorative dentistry. It occurs through the hydrolysis of adhesive resin and the breakdown of collagen fibrils by endogenous proteases especially matrix metalloproteinases (MMPs). Hydrolysis occurs when the water acts as medium for chemical bonds breakdown especially methacrylate based resin containing ester bond that is vulnerable for this process. MMPs are embedded in the dentin during tooth development. These enzymes are activated by acid during dentin demineralization of etch-and-rinse and self-etch adhesive system. Since adhesive resin infiltration is often incomplete, denuded collagen fibrils associated with water can be enzymatically digested, eventually contributing to the hybrid layer deterioration. This review describes the mechanism of hybrid layer degradation and the potential strategies to slow down this process.