運動對幹細胞之影響

10.6162/SRR.2009.100.26

黃森芳；陳東韋

增殖 ； 分化 ； 修護

大專體育

100期（2009 / 02 / 01）

186 - 193

繁體中文

細胞具有複製與自己完全一樣與分化為成熟組織的細胞，扮演著人體出生後組織傷害後修護、更新，維持組織器官與身體健康之重要角色。因此，臨床上的應用，幹細胞可能是未來人類治療癌症、中風、心肌壞死、阿茲海默症、老人癡呆或糖尿病等組織細胞再生或組織器官損傷性疾病的希望。近年來，愈來愈多的動物與人體實驗證實，運動不只會動員骨髓的中各類幹細胞進入血液循環中，同時對於血管幹細胞、肌肉中的衛星幹細胞、腦部海馬迴內齒狀迴神經幹細胞的增殖、分化功能等，都有顯著的促進作用。而這些幹細胞運動後反應現象，確實進一步的提供了運動強化人體修護能力、延緩老化與促進健康的有利支持證據，未來研究應針對上述運動對幹細胞影響的機制，進一步釐清與探究。

1. National Institutes of Health, U.S. Department of Health and Human Services. (2008a). Stem cell basics. Retrieved August 24, 2008, from Stem Cell Information Web Site: http://stemcells.nih.gov/info/basics/defaultpage
2. National Institutes of Health, U.S. Department of Health and Human Services. (2008b). Stem cell basics .Retrieved October 24, 2008, from Stem Cell Information Web Site: http://stemcells.nih.gov/staticresources/info/scireport/PDFs/appendixe.pdf
3. Bonsignore, M. R.,Morici, G.,Santoro, A.,Pagano, M.,Cascio, L.,Bonanno, A.(2002).Circulating hematopoietic progenitor cells in runners.Journal of Applied Physiology,93,1691-1697.
4. Hoetzer, G. L.,Van Guilder, G. P.,Irmiger, H. M.,Keith, R. S.,Stauffer, B. L.,Desouza, C. A.(2007).Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men.Journal of Applied Physiology,102,847-852.
5. Kim, Y. P.,Kim, H.,Shin, M. S.,Chang, H. K.,Jang, M. H.,Shin, M. C.(2004).Age-dependent of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats.Neuroscience Letters,355,152-154.
6. Kronenberg, G.,Bick-Sander, A.,Bunk, E.,Wolf, C.,Ehninger, D.,Kempermann, G.(2006).Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus.Neurobiology of Aging,27,1505-1513.
7. Laufs, U.,Urhausen, A.,Werner, N.,Scharhag, J.,Heitz, A.,Kissner, G.(2005).Running exercise of different duration and intensity: Effect on endothelial genitor cells in healthy subjects.European Journal of Cardiovascular Prevention and Rehabilitation,12(4),407-414.
8. Palermo, A. T.,Larbarge, M. A.,Doyonnas, R.,Pomerantz, J.,Blau, H. M.(2005).Bone marrow contribution to skeletal muscle: A physiological response to stress.Developmental Biology,279,336-344.
9. Parise, G.,McKinnell, I. W.,Rudnicki, M. A.(2008).Muscle satellite cell and atypical myogenic progenitor response following exercise.Muscle Nerve,37,611-619.
10. Rehman, J.,Li, J.,Parvathaneni, L.,Karlsson, G.,Panchal, V. R.,Temm, C. J.(2004).Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells.Journal of the American College of Cardiology,43(12),2314-2318.
11. Sandri, M.,Adams, V.,Gielen, S.,Linke, A.,Lenk, K.,Kränkel, N.(2005).Effects of exercise and ischemia on mobilization and functional activation of blood-drived progenitor cells in patients with ischenic symdrome: Results of 3 randomized studies.Circulation,111,3391-3399.
12. Shefer, G.,Carmeli, E.,Rauner, G.,Yablonky-Reuveni, Z.,Benayhu, D.(2008).Exercise running and tetracycline as means to enhance skeletal muscle stem cell performance after external fixation.Journal of Cellular Physiology,215,265-275.
13. Uda, M.,Ishido, M.,Kami, K.,Masuhara, M.(2006).Effects of chronic treadmill running on neurogenesis in the dentate gyrus of the hippocampus of adult rat.Brain Research,1104,64-72.
14. Wahl, P.,Brixius, K.,Bloch, W.(2008).Exercise-induced stem cell activation and its implication for cardiovascular and skeletal muscle regeneration.Minimally Invasive Therapy,17(2),91-99.

1. 張庭慈(2016)。運動專項對選擇反應與認知控制的影響。中山醫學大學心理學系暨臨床心理學碩士班學位論文。2016。1-102。